慶應義塾大学 · 医学
福田圭一教授の研究室では、心臓の神経調節機構と心筋細胞の再生医療を柱とした基礎研究を進めています。特に、心臓の副交感神経・交感神経による機能調節の神経循環フィードバック機構の解明や、骨髄由来の心筋細胞様細胞（CMG細胞）の樹立・機能解析を通じて、心筋再生の可能性を追求しています。心電生理学的・分子生物学的アプローチを融合させた、心臓の生体恒常性と再生のメカニズム解明が主な研究方向性です。
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Afferent and efferent cardiac neurotransmission via the cardiac nerves intricately modulates nearly all physiological functions of the heart (chronotropy, dromotropy, lusitropy, and inotropy). Afferent information from the heart is transmitted to higher levels of the nervous system for processing (intrinsic cardiac nervous system, extracardiac-intrathoracic ganglia, spinal cord, brain stem, and higher centers), which ultimately results in efferent cardiomotor neural impulses (via the sympathetic
We have isolated a cardiomyogenic (CMG) cell line from murine bone marrow stroma. Stromal cells were immortalized, treated with 5-azacytidine, and spontaneous beating cells were repeatedly screened for. The cells showed a fibroblast-like morphology. However, this morphology changed after 5-azacytidine treatment in about 30% of the cells, which connected with adjoining cells after 1 week, formed myotube-like structures and began spontaneous beating after 2 weeks, and beat synchronously after 3 we
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