東北大学 · 生化学・遺伝学・分子生物学
Keiko Nakayama教授の研究室では、細胞死と細胞周期の制御が発生とがん化に与える影響を、マウスモデルを用いて分子機構的に解明しています。特にBcl-2遺伝子の機能と、細胞周期キナーゼ阻害酵素（CKIs）の発生・腫瘍形成における役割に注目し、細胞の生存・死のバランスと細胞周期の制御機構を解析しています。
Figures are computed from collected data and may differ slightly.
Mice carrying ablated coding regions of the bcl-2 alpha and bcl-2 beta transcripts have been made. bcl-2-/- mutants are smaller but viable, although about half of them die by 6 weeks of age. As shown earlier with somatic bcl-2 gene-targeted mice, the number of lymphocytes markedly decreased within few weeks after birth while other hematopoietic lineages remained unaffected. Among lymphocytes, CD8+ T cells disappeared most quickly followed by CD4+ T cells, whereas B cells were least affected. bcl
Precise control of cell-cycle progression is believed to be critical for normal development, while oncogenesis may be a direct result of its disturbance. Cell-cycle progression is regulated predominantly by a series of serine/threonine kinases, the cyclin-dependent kinases (CDKs). The activities of the CDKs are controlled by a variety of mechanisms, and a group of molecules that inhibit CDK activity, CDK inhibitors (CKIs), has recently become the focus of interest, particularly in the fields of
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