大阪大学 · 医学
東教授の研究室は、脳卒中の発症メカニズムと急性治療戦略の解明を柱としています。特に、朝起きた直後に発症する脳卒中が、睡眠中に急激に進行している可能性を画像診断で示しており、早期治療の可能性を追求しています。また、心房性期外収縮（PAC）が脳塞栓症の予備的要因である可能性を解明し、インテリジェントな心電モニタリングの重要性を提唱しています。さらに、奇形血管や血栓のメカニズムに着目した、脳卒中の予防的・治療的アプローチの確立を目指しています。
Figures are computed from collected data and may differ slightly.
Based on our CT findings, stroke at awakening seems to be developing shortly before in a large subset of patients, making them potential candidates for acute stroke therapies.
After CCA occlusion, GM-CSF treatment enhanced leptomeningeal collateral growth and decreased the infarct size after MCA occlusion in mice.
We report a case of recurrent paradoxical brain embolism mediated through a small pulmonary arteriovenous malformation (PAVM) with a 1.8-mm-diameter feeding artery. In this case, the further recurrent stroke was prevented successfully by PAVM embolization. Although embolization therapy is currently recommended only for PAVMs with feeding arteries greater than 3 mm in diameter, the therapy may be needed also in the smaller PAVMs.
Our data suggest that frequent PAC should be regarded as a masked type of paroxysmal atrial fibrillation and should be included in one of the causes of cardioembolic stroke.
High frequency of PACs in cryptogenic stroke may be a strong predictor of AF detected by ICM.
Open papers in the app to read, cite, and organize with AI.
