九州大学 · 生化学・遺伝学・分子生物学
Hamase教授の研究室では、生体に存在するD-アミノ酸の分析技術開発に注力しており、特にガスクロマトグラフィーおよび高効率液体クロマトグラフィーを応用した高感度・高選択性の分析法を確立しています。マウス脳におけるD-アスパラギン酸、D-セリン、D-アルアニンなどのD-アミノ酸の分布解明や、D-アミノ酸オキシダーゼの代謝的役割の解明も進めています。臨床応用では、慢性腎疾患患者の血液中で上昇するD-アミノ酸の正確な定量を目的とした3次元HPLCシステムの開発も行われており、医療応用に向けた分析技術の基盤を築いています。
Figures are computed from collected data and may differ slightly.
The determination of small amounts of D-amino acids in mammalian tissues is still a challenging theme in the separation sciences. In this review, various gas-chromatographic and high-performance liquid chromatographic methods are discussed including highly selective and sensitive column-switching procedures. Based on these methods, the distributions of D-aspartic acid, D-serine, D-alanine, D-leucine and D-proline have been clarified in the mouse brain. As the regulation mechanisms of D-amino aci
The concentrations of several d-amino acids have been reported to significantly increase in the plasma of patients with chronic kidney disease (CKD). However, the amounts of these d-amino acids are low (around 1% of the l-form or lower), and their analyses were complicated by various interfering compounds in many clinical samples. A highly selective analytical method is thus required to perform the accurate and precise determination of these d-amino acids in the plasma of CKD patients. In the pr
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