東京大学 · 免疫学・微生物学
Kensuke Miyake教授の研究室では、B細胞の機能制御に関与する膜分子の機能解明を柱としており、特にRP105というレセプターがB細胞の生存と増殖に与えるシグナル伝達機構を分子・細胞生物学的手法を用いて解析しています。放射線やステロイドに起因する細胞死からの保護機構の解明は、がん治療や自己免疫疾患の治療戦略の開発にも応用が期待されます。
Figures are computed from collected data and may differ slightly.
The RP105 Ag is a murine B cell surface molecule that transmits an activation signal into B cells following ligation with anti-RP105 mAb. The activation leads to protection of B cells from irradiation- or dexamethasone-induced apoptosis, and to B cell proliferation. A cDNA encoding the RP105 Ag was isolated. An encoded protein is a type I transmembrane protein consisting of 641 amino acids in a mature form. Northern hybridization with a probe specific for the cDNA clone detected a transcript wit
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