名古屋大学 · 医学
岸教授の研究室は、肥満や代謝症候群に伴う循環器・代謝疾患の発症メカニズムを解明するため、脂肪細胞から分泌されるホルモン・アディポネクチンの多様な生理的・病態修飾的役割に注目しています。特に、マ Acro膵細胞の極性制御や血管新生、腎障害への保護作用といった、アディポネクチンが免疫・炎症反応や酸化的なストレスに与える影響を分子・細胞レベルで解明しています。また、動物モデルや細胞系を用いた機能解析を通じて、アディポネクチンの治療的応用可能性を追求しています。
Figures are computed from collected data and may differ slightly.
It is established that the adipocyte-derived cytokine adiponectin protects against cardiovascular and metabolic diseases, but the effect of this adipokine on macrophage polarization, an important mediator of disease progression, has never been assessed. We hypothesized that adiponectin modulates macrophage polarization from that resembling a classically activated M1 phenotype to that resembling alternatively-activated M2 cells. Peritoneal macrophages and the stromal vascular fraction (SVF) cells
Patients with obesity are susceptible to hypertension. We have reported that the plasma adiponectin levels are decreased in obesity and that adiponectin has many defensive properties against obesity-related diseases, such as type 2 diabetes and coronary artery disease. The aim of this study was to determine the relationship between adiponectin and hypertension in mice. We measured blood pressure and heart rate directly by a catheter in the carotid artery and indirectly by automatic sphygmomanome
Adiponectin accumulates to the injured kidney, and prevents glomerular and tubulointerstitial injury through modulating inflammation and oxidative stress.
Adiponectin is a fat-derived plasma protein that has cardioprotective roles in obesity-linked diseases. Because cyclooxygenase 2 (COX-2) is an important modulator of endothelial function, we investigated the possible contribution of COX-2 to adiponectin-mediated vascular responses in a mouse hind limb model of vascular insufficiency. Ischemic insult increased COX-2 expression in endothelial cells of wild-type mice, but this induction was attenuated in adiponectin knockout mice. Ischemia-induced
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