Kuen Yong Lee

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrogels for Tissue EngineeringKuen Yong Lee and David J. MooneyView Author Information Departments of Biologic & Materials Sciences, Chemical Engineering, and Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109 Cite this: Chem. Rev. 2001, 101, 7, 1869–1880Publication Date (Web):May 31, 2001Publication History Received15 November 2000Published online31 May 2001Published inissue 1 July 2001https://pubs.acs.org/doi/10.1021/cr000108

ADVERTISEMENT RETURN TO ISSUEPREVNoteControlling Mechanical and Swelling Properties of Alginate Hydrogels Independently by Cross-Linker Type and Cross-Linking DensityKuen Yong Lee, Jon A. Rowley, Petra Eiselt, Erick M. Moy, Kamal H. Bouhadir, and David J. MooneyView Author Information Department of Biomedical Engineering, Chemical Engineering, Biologic & Materials Sciences, and Materials Science & Engineering, University of Michigan, Ann Arbor, Michigan 48109 Cite this: Macromolecules 2000, 33,

Hydrophobically modified chitosan derivatives containing 0.6−5.1 deoxycholic acid groups per 100 anhydroglucose units of chitosan were synthesized by an EDC-mediated coupling reaction. Self-aggregates of the chitosan derivatives in aqueous media were formed by sonication with a probe-type sonifier. The mean diameter of self-aggregates determined by dynamic light scattering decreased slightly with an increasing degree of substitution (DS) by hydrophobic groups. Photophysical and photochemical cha

There is a significant need in the biomedical field for hydrogels with controllable mechanical and degradative properties. We now report the degradation behavior of novel hydrogels formed by the cross-linking of poly(aldehyde guluronate) (PAG). PAG was prepared from alginate by acid hydrolysis and oxidation and was covalently cross-linked with adipic acid dihydrazide (AAD) to form hydrogels. These hydrogels were degradable in aqueous media due to the hydrolysis of hydrazone bonds formed between

Degradable and injectable hydrogels may be ideal for bone-tissue engineering, especially in the craniofacial region because of the ease of access for injection. Alginate hydrogels potentially could be used as injectable cell delivery vehicles, but they exhibit a limited range of mechanical properties and uncontrollable disintegration time. Therefore we synthesized new hydrogels, composed of poly(aldehyde guluronate) (PAG) and adipic acid dihydrazide, that have a wide range of mechanical stiffnes

It was hypothesized that nanoscale adhesion ligand spacing regulates cell adhesion, proliferation, and differentiation, and that this control can be decoupled from the overall ligand density. Alginate was chemically modified with a peptide containing the cell adhesion sequence arginine-glycine-aspartic acid (RGD), and the nanoscale spacing of RGD ligands in alginate gels was varied. A decrease in the RGD island spacing from 78 to 36 nm upregulated the proliferation rates of MC3T3-E1 cells from 0

Development of biomaterial-based bioinks is critical for replacement and/or regeneration of tissues and organs by three-dimensional (3D) printing techniques. However, the number of 3D-printable biomaterials in practical use remains limited despite the rapid development of 3D printing techniques. Controlling the flow properties of bioinks and mechanical properties of the resultant printed objects is key considerations in the design of biomaterial-based bioinks for practical applications. In this