Korea University · 医学
Professor Kyoung Jin Kim's research lab specializes in clinical and translational dermatology, with a focus on inflammatory and autoimmune skin disorders such as erythema annulare centrifugum, as well as the pathological mechanisms underlying cutaneous reactions to medical implants like Artecoll. The lab also investigates metabolic and cardiovascular complications in diabetes and hypertension, particularly the long-term impact of glycemic control and hormonal imbalances—such as in primary aldosteronism—on atrial fibrillation risk. Additionally, the lab explores molecular pathways in cancer metastasis, particularly the role of signaling molecules like protein kinase CK2 and platelet-activating factor in NF-κB activation and tumor progression.
Figures are computed from collected data and may differ slightly.
The combination of anti-PD-L1 and radiation significantly improved the antitumor effect shown in tumor growth delay as well as in survival, supporting a novel combination strategy of immunoradiotherapy in HCC.
Erythema annulare centrifugum (EAC) denotes a group of eruptions characterized by slowly migrating annular or configurate erythematous lesions. It can be classified histopathologically as the deep or superficial type. Although there are many case reports of EAC associated with various underlying conditions, no recent clinicopathologic studies exist. The purpose of this study was aimed at analyzing the clinical and histopathologic features of EAC. Sixty-six patients who have been diagnosed as EAC
In this study, the prevalence of frailty was found to vary depending on the scale used. Efforts aimed at screening and providing intervention for frailty and frail adults at risk, respectively, are needed to improve health outcomes considering the characteristics of each frailty scale and the determined prevalence.
Early target HbA1c achievement was associated with long-term durable glycemic control and reduced risk of diabetic complications in newly diagnosed T2DM.
To our knowledge, this case is the first report of an extensive Artecoll-induced granuloma on the neck. Our findings suggest that Artecoll not be used as implant material in thin and constantly movable skin, such as that of the neck.
Waste to energy technology is attracting attention to overcome the upcoming environmental and energy issues. One of the key-steps is the water-gas shift (WGS) reaction, which can convert the waste-derived synthesis gas (H2 and CO) to pure hydrogen. Co–CeO2 catalysts were synthesized by the different methods to derive the optimal synthetic method and to investigate the effect of the preparation method on the physicochemical characteristics of Co–CeO2 catalysts in the high-temperature water-gas sh
Background: To estimate and compare the trends of all-cause and cause-specific mortality rates for subjects with and without diabetes in South Korea, from 2003 to 2013. Methods: Using a population-based cohort (2003 to 2013), we evaluated annual mortality rates in adults (≥30 years) with and without diabetes. The number of subjects in this analysis ranged from 585,795 in 2003 to 670,020 in 2013. Results: Age- and sex-adjusted all-cause mortality rates decreased consistently in both groups from 2
This real-world database analysis showed that DPP4i therapy did not increase the overall risk of major cardiovascular and renal outcomes compared to SU therapy. However, the DPP4i-associated risk of HHF remained significant.
Increased risk of atrial fibrillation was reported in patients with primary aldosteronism. However, data are limited regarding the time-dependent risk of atrial fibrillation in surgically or medically treated primary aldosteronism. From the National Health Insurance Claim database in Korea (2003–2017), a total of 1418 patients with primary aldosteronism (adrenalectomy [ADX], n=755, mineralocorticoid receptor antagonist n=663) were age- and sex-matched at a 1:5 ratios to patients with essential h
Platelet-activating factor (PAF) promotes tumour metastasis via activation of the transcription factor nuclear factor-κB (NF-κB). We here investigated the role of the protein kinase CK2 (formerly Casein Kinase 2 or II) in PAF-induced NF-κB activation and tumour metastasis, given that PAF has been reported to increase CK2 activity, and that CK2 plays a key role in NF-κB activation. PAF increased CK2 activity, phosphorylation and protein expression in vivo as well as in vitro. CK2 inhibitors inhib
Misdiagnosis is frequent in scabies of infants and children because of a low index of suspicion, secondary eczematous changes, and inappropriate therapy. Topical or systemic corticosteroids may modify the clinical presentation of scabies and that situation is referred to as scabies incognito. We describe a 10-month-old infant with scabies incognito mimicking urticaria pigmentosa.
These results demonstrate that HO-1 is a target site and an antioxidant mediator of simvastatin in human RPE cells. Simvastatin-dependent upregulation of HO-1 is mainly via PI3K/Akt-dependent signaling pathways. Simvastatin may have some clinical benefits in preventing retinal diseases associated with oxidative stress, such as AMD.
Early achievement of HbA1c level within the glycemic target was a determinant of long-term glycemic durability in new-onset T2DM, as were higher levels of education, physical activity, and HOMA-β.
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