Lin Wang

Macrophage polarization toward M1 phenotype (pro-inflammation) is closely associated with the destructive phase of periodontal inflammation. Nanoceria is verified to inhibit M1 polarization of macrophages by the favorable ability of reactive oxygen species (ROS) scavenging. However, the function of nanoceria on macrophage polarization toward M2 phenotype (anti-inflammation) in reparative phase of periodontal inflammation is quite limited. In this work, by introducing an antioxidant drug querceti

Numerous nanomedicines currently emerge to reduce the dramatic threat in antibiotics resistance for antibacterial application against severe bacterial infections, while it is restricted by over-reacted immune response to pathogenic bacteria. Herein, enzymatic activity is introduced into the zeolitic imidazolate framework-8 (ZIF-8) to achieve sterilization by releasing Zn ions, as well as inflammation regulation through the variable valence of Mn ions that are uniformly doped into its framework.

Infectious diseases caused by bacteria remain a serious and global problem in human health. Herein, the discovery and application of antibiotics, which has attracted much attention in the past years, has cured numerous infectious diseases and made huge contribution in biomedical field. However, the widespread use of the broad-spectrum antibiotics has led to the serious drug resistance for many human bacterial pathogens. Especially, the bacterial drug resistance decreases the therapeutic effect a

The repair of infected bone defects with irregular shapes is still a challenge in clinical work. Infected bone defects are faced with several major concerns: the complex shapes of bone defects, intractable bacterial infection and insufficient osseointegration. To solve these problems, we developed a personalized MXene composite hydrogel scaffold GelMA/β-TCP/sodium alginate (Sr²⁺)/MXene (Ti₃C₂) (GTAM) with photothermal antibacterial and osteogenic abilities by 3D

Abstract The hypoxic microenvironment, continuous oxygen consumption, and poor excitation light penetration depth during antimicrobial photodynamic therapy (aPDT) tremendously hinder the effects on bacterial inactivation. Herein, a smart nanocomposite with oxygen‐self‐generation is presented for enhanced and selective antibacterial properties against anaerobe‐induced periodontal diseases. By encapsulating Fe 3 O 4 nanoparticles, Chlorin e6 and Coumarin 6 in the amphiphilic silane, combined light

Periodontitis is a common bacteria-borne inflammatory disease that can damage the supporting structures of teeth, eventually leading to tooth loss and systemic inflammations. The present study developed novel nanoparticles (ZIF-8:Ce) by doping cerium (Ce) into zeolitic imidazolate framework-8 (ZIF-8) to simultaneously obtain antibacterial and anti-inflammatory capabilities. The objectives of this study were to: (1) develop novel ZIF-8 nanoparticles doped with different Ce/(Ce + Zn) molar ratios

Periodontitis is a common infectious disease characterized by loss of tooth-supporting structures, which eventually leads to tooth loss. The heavy burden of periodontal disease and its negative consequence on the patient's quality of life indicate a strong need for developing effective therapies. According to the World Health Organization, 10⁻15% of the global population suffers from severe periodontitis. Advances in understanding the etiology, epidemiology and microbiology of periodontal pocket

It is an effective way in bone tissue engineering to promote the mechanical and osteogenic capability of hydrogels by encapsulating mineral particles into polymer matrix. In this work, we reported novel kinds of nanocomposite scaffolds based on hydroxypropyl chitosan/aldehyde dextran hydrogel (CDH) and strontium-nanohydroxyapatite (Sr-nHA) nanoparticles. The molar ratios of Sr/(Sr + Ca) at 0% (nHA), 50% (Sr50nHA), and 100% (Sr100nHA) were fabricated and subsequently incorporated into CDH. The ch

Multilayer films containing microgels of chemically cross-linked poly(allylamine hydrochloride) (PAH) and dextran (named PAH-D) were fabricated by layer-by-layer deposition of PAH-D and poly(styrene sulfonate) (PSS). The successful fabrication of PAH-D/PSS multilayer films was verified by quartz crystal microbalance measurements and cross-sectional scanning electron microscopy. The as-prepared PAH-D/PSS multilayer films can reversibly load and release negatively charged dyes such as methyl orang