Ling Kang

To evaluate potential mechanisms for neuronal glucosensing, fura-2 Ca(2+) imaging and single-cell RT-PCR were carried out in dissociated ventromedial hypothalamic nucleus (VMN) neurons. Glucose-excited (GE) neurons increased and glucose-inhibited (GI) neurons decreased intracellular Ca(2+) ([Ca(2+)](i)) oscillations as glucose increased from 0.5 to 2.5 mmol/l. The Kir6.2 subunit mRNA of the ATP-sensitive K(+) channel was expressed in 42% of GE and GI neurons, but only 15% of nonglucosensing (NG)

Battery-type materials for supercapacitors have attracted increasing research interest owing to their high energy density. However, their poor electrode kinetics severely limit the utilization of redox-active sites on the electrode surface, resulting in subpar electrochemical performance. Herein, we incorporate both Cu dopants and O vacancies into Co3O4 nanocrystals confined in a carbon matrix (Ov-Cu-Co3O4@C) which are assembled into nanowires. This heterostructured architecture with multifuncti

Nickel cobalt sulfide (NiCo₂S₄) is a promising battery-type material for electrochemical energy storage.

To test the hypothesis that glucokinase is a critical regulator of neuronal glucosensing, glucokinase activity was increased, using a glucokinase activator drug, or decreased, using RNA interference combined with calcium imaging in freshly dissociated ventromedial hypothalamic nucleus (VMN) neurons or primary ventromedial hypothalamus (VMH; VMN plus arcuate nucleus) cultures. To assess the validity of our approach, we first showed that glucose-induced (0.5-2.5 mmol/l) changes in intracellular Ca

Molybdenum sulfide (MoS₂) is a promising electrode material for supercapacitors; however, its limited Mo/S edge sites and intrinsic inert basal plane give rise to sluggish active electronic states, thus constraining its electrochemical performance. Here we propose a hierarchical confinement strategy to develop ethylene molecule (EG)-intercalated Co-doped sulfur-deficient MoS₂ (Co-EG/S_V-MoS₂) for efficient and durable K-ion storage. Theoretical analyses

As a typical battery-type material, CuCo₂ S₄ is a promising candidate for supercapacitors due to the high theoretical specific capacity. However, its practical application is plagued by inherently sluggish ion diffusion kinetics and inferior electrical transport properties. Herein, sulfur vacancies are incorporated in CuCo₂ S₄ hollow nanoarchitectures (HNs) to accelerate redox reactivity. Experimental analyses and theoretical investigations uncover tha

Two-dimensional layered transition metal dichalcogenides (2D TMDs) have emerged as promising candidates for supercapacitor (SCs) owing to their tunable electronic properties, layered structures, and effective ion intercalation capabilities. Despite these advantages, challenges such as low electrical conductivity, the interlayer restacking, oxidation and structural collapse hinder their practical implementation. This review provides a comprehensive overview of recent advances in the development o

Antecedent insulin-induced hypoglycemia (IIH) reduces adrenomedullary responses (AMR) to subsequent bouts of hypoglycemia. The ventromedial hypothalamus [VMH: arcuate (ARC) + ventromedial nuclei] contains glucosensing neurons, which are thought to be mediators of these AMR. Since type 1 diabetes mellitus often begins in childhood, we used juvenile (4- to 5-wk-old) rats to demonstrate that a single bout of IIH (5 U/kg sc) reduced plasma glucose by 24% and peak epinephrine by 59% 1 day later. This