大阪大学 · 医学
福本学教授の研究室は、自己免疫疾患、特に皮膚筋炎や抗スインセターゼ抗体関連症候群（抗-ARS抗体陽性疾患）の発症メカニズムとそのバイオマーカーの解明を柱としています。特に、抗核抗体のサブタイプと疾患の臨床像・予後との関連を解析し、疾患の分類と個別化医療の実現に貢献しています。また、B細胞受容体シグナル伝達の分子機構や、自己抗体の産生メカニズムについても深く研究しています。
Figures are computed from collected data and may differ slightly.
Patients with anti-ARS Abs are relatively homogeneous. However, the distribution and timing of myositis, ILD, and rashes differ among patients with individual anti-ARS Abs. Thus, identification of individual anti-ARS Abs is beneficial to define this rather homogeneous subset and to predict clinical outcomes within the "anti-synthetase syndrome."
This novel MSA is associated with cancer-associated DM and may serve as a diagnostic serological marker for this specific subset.
Anti-155/140 antibodies target TIF-1 family proteins, TIF-1α and TIF-1β, in addition to TIF-1γ. Since TIF-1 proteins have significant roles in oncogenesis, these antibodies may be produced during misdirected antitumor immunity.
'Autoantibody-based classification' of dermatomyositis subsets is now a useful strategy for comprehending the heterogeneous spectrum of dermatomyositis.
Ligation of the B cell Ag receptor (BCR) induces cellular activation by stimulating Src-family protein tyrosine kinases (PTKs) to phosphorylate members of the BCR complex. Subsequently, Src-family PTKs, particularly Lyn, are proposed to phosphorylate and bind CD19, a cell-surface costimulatory molecule that regulates mature B cell activation. Herein, we show that B cells from CD19-deficient mice have diminished Lyn kinase activity and BCR phosphorylation following BCR ligation. Tyrosine phosphor
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