東京大学 · 医学
佐藤正明教授の研究室では、肺移植後の慢性拒絶反応、特に閉塞性細気管支炎（OB）の発症機構に注目し、小気道に形成される新生リンパ組織や高内皮静脈（HEV）の役割を解明しています。特に、CLAD（慢性肺障害）の発症に先行してリンパ組織新生が起こり、その過程でストーマル細胞が活性化されることを見いだしています。また、画像ガイドド手術技術「VAL-MAP」を活用した胸腔鏡下肺節切除術の高度化にも貢献しています。
Figures are computed from collected data and may differ slightly.
Chronic rejection after lung transplantation is manifested as obliterative bronchiolitis (OB). The development of de novo lymphoid tissue (lymphoid neogenesis) may contribute to local immune responses in small airways. Compared with normal lungs, the lung tissue of 13 lung transplant recipients who developed OB demonstrated a significantly larger number of small, airway-associated, peripheral node addressin-positive (PNAd(+)) high endothelial venules (HEVs) unique to lymphoid tissue (p < 0.001).
UMIN 000008031. University Hospital Medical Information Network Clinical Trial Registry ( http://www.umin.ac.jp/ctr/ ).
Anatomical segmentectomies play an important role in oncological lung resection, particularly for ground-glass types of primary lung cancers. This operation can also be applied to metastatic lung tumors deep in the lung. Virtual assisted lung mapping (VAL-MAP) is a novel technique that allows for bronchoscopic multi-spot dye markings to provide "geometric information" to the lung surface, using three-dimensional virtual images. In addition to wedge resections, VAL-MAP has been found to be useful
Lymphoid neogenesis associated with CLAD accompanies activation of stromal resident cells and formation of lymphoid-like stroma. Induction of PNAd+ HEV-like vessels occurs before the manifestation of CLAD.
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