東北大学 · 医学
Kohzuki教授の研究室は、高血圧と糖尿病に伴う臓器障害、特に腎機能障害の発症メカニズムと、アンジオテンシン系阻害薬による臓器保護作用を、ラットモデルを用いて解明しています。特に、ACE阻害薬やARBの長期投与が腎機能に与える影響、および血圧降下効果と腎保護作用の相違を解明する独自の測定法の開発にも注力しています。
Figures are computed from collected data and may differ slightly.
These results suggest that exercise does not worsen renal function and has renal-protective effects in this model of rats. Moreover, the antihypertensive therapy has additional renal-protective effects in this model of rats.
These results indicate that hypertension could accelerate diabetic renal impairment and that losartan has antihypertensive and renoprotective effects in this rat model. They also suggest that the antihypertensive and renoprotective effects of captopril treatment in this rat model are caused mainly by inhibition of angiotensin II production rather than stimulation of the kallikrein-kinin system or of vasodilator prostaglandins. The difference in potency between losartan treatment and captopril tr
Angiotensin converting enzyme (ACE) inhibitors lead to induction of ACE in animals and humans. This complicates the use of ACE enzymatic activity as an index of inhibition in plasma or tissues after chronic administration of ACE inhibitors. We have, therefore, developed a method for ACE measurement by in vitro autoradiography using an 125I-labelled inhibitor to quantitate total ACE and the concentration of free (not inhibited) ACE in tissues after prolonged administration of ACE inhibitors to ra
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