東北大学 · 医学
Masaki Nio教授の研究室は、小児肝胆道疾患、特に胆道閉鎖症の早期診断と治療成績の向上を主眼としています。特に Kasai手術の適切な時期（術後生存率や長期予後との関連）の解明に注力しており、日本全国の胆道閉鎖症登録データを活用した大規模疫学的解析も実施しています。また、小児における胸腔鏡下手術の安全性と有効性の検証も進めており、治療の最小侵襲化を追求しています。
Figures are computed from collected data and may differ slightly.
There are discrepancies regarding the clinical impact of age at Kasai portoenterostomy (KP) on surgical outcomes. Hence, we re-assessed the clinical significance of age at KP. We analyzed 224 patients with type III (atresia of bile duct at the porta hepatis) biliary atresia at Tohoku University Hospital. We classified patients into two groups: KP at ≤60 days of age (group TE) and >60 days of age (group TL). Group TE was subdivided into three groups (TE1, TE2, and TE3) according to age at time of
Between 1953 and 1995, 300 patients with biliary atresia underwent surgery at Tohoku University Hospital. The 10-year survival of patients who were operated on in or before 1965 was 9%. But the survival rate went up to 61% in patients operated on between 1976 and 1985. Eighty-five patients including 2 who developed liver failure after Kasai operation and underwent liver transplantation have survived more than 10 years. Eleven of them (13%) have recurrent or persistent jaundice. Of the 30 patient
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