東京大学 · 医学
福山正史教授の研究室では、胃がんの発症メカニズムに注目し、特にエプスタイン・バーウイルス（EBV）関連胃がんの発生とそのバイオマーカーの同定を主な研究テーマとしています。また、神経線維腫症に合併する胃腸基質腫瘍（GIST）の特徴や、がん関連抗原としてのSALL4の意義についても、免疫染色と遺伝子異常解析を組み合わせた病理学的アプローチを展開しています。がんの早期診断や個別化医療に貢献する分子標識の解明が、研究の柱です。
Figures are computed from collected data and may differ slightly.
EBV may infect the surface epithelium of the stomach through the reactivated EBV-carrying lymphocytes. EBV may be a factor initiating EBVaGC. Anti-EBV antibodies or EBER1 in situ hybridization may help to identify patients at high risk for EBVaGC.
Gastrointestinal stromal tumor (GIST), as well as the hyperplastic lesions of intestinal neural tissue and its supporting structures, is a gastrointestinal complication of type 1 neurofibromatosis (NF1) (von Recklinghausen's disease). In the present study, we analyzed the histologic and immunohistochemical features, and the c-kit and PDGFRA gene mutations of 36 GISTs derived from 9 NF1 patients. Distinctively, multiple GISTs arose preferentially in the small intestine. The histologic features of
The novel stem cell marker SALL4 has been identified as a diagnostic marker of germ cell tumors, especially yolk sac tumors, in gonadal organs. To clarify the significance of SALL4 as an oncofetal protein, we investigated SALL4 expression by immunohistochemistry in non-neoplastic stomach and gastric carcinoma with particular emphasis on á-fetoprotein (AFP)-producing gastric carcinoma, as AFP-producing gastric carcinoma shares expression of AFP and glypican 3 (GPC3) with yolk sac tumors and hepat
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