九州大学 · 生化学・遺伝学・分子生物学
Masato Akiyama教授の研究室では、日本人を対象としたゲノムワイド解析を通じて、身長の遺伝的構造を解明しています。特に、希少・低頻度バリアントに注目し、日本集団ならではの遺伝的要因の同定を進めています。ゲノムインプリンティングや遺伝子統合解析を応用し、複雑な形質の遺伝的基盤を解明する研究が中心です。
Figures are computed from collected data and may differ slightly.
Human height is a representative phenotype to elucidate genetic architecture. However, the majority of large studies have been performed in European population. To investigate the rare and low-frequency variants associated with height, we construct a reference panel (N = 3,541) for genotype imputation by integrating the whole-genome sequence data from 1,037 Japanese with that of the 1000 Genomes Project, and perform a genome-wide association study in 191,787 Japanese. We report 573 height-associ
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