京都大学 · 生化学・遺伝学・分子生物学
Tsukahara教授の研究室は、再生医療に不可欠なヒト induced 人工多能性幹細胞（hiPSC）の接着・生存・分化制御を、細胞外マトリックスとシグナル伝達機構の観点から解明しています。特に laminin-511 と α6β1 インテグリンが E-cadherin と協働して細胞死を回避するシグナル経路を解明しており、iPSCの安定な培養と臨床応用に向けた基盤を構築しています。また、個別患者向けのiPSC治療を実現するための3Dクローズドプロダクションシステムの開発も進めています。
Figures are computed from collected data and may differ slightly.
This study was supported by a research center network for the realization of regenerative medicine of the Japan Agency for Medical Research and Development (AMED) under grant number JP20bm0104001h0108.
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