Masayuki Akashi

OIT is effective in increasing the threshold for allergens and inducing desensitization in Japanese egg allergy patients, similarly to North American and European patients.

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy with gastrointestinal symptoms such as vomiting and diarrhea. The development of international consensus guidelines for the diagnosis and management of FPIES in 2017 enabled us to compare patients worldwide, regardless of geographic variation in disease features. As a result, it has become clear that there is heterogeneity among patients with FPIES or that there are cases that partly fit the diagnostic criteri

Severe AD is a disease that should be cautiously treated because of the risk of hypoproteinemia, growth impairment, electrolyte abnormalities, and thrombocytosis; however, it should be noted that appropriate treatments can improve this condition.

Food protein-induced enterocolitis syndrome (FPIES) is a type of non-IgE-mediated gastrointestinal food allergy. FPIES is characterized by repetitive vomiting without classic IgE-mediated allergic skin or respiratory symptoms 1-4 h after causative food ingestion. The condition may be classified as acute or chronic, typical or atypical, and liquid or solid according to the course of symptoms, presence of IgE antibodies, and causative food, respectively. Since the development of international cons

日本語版 ISAAC（International Study of Asthma and Allergies in Childhood）調査用紙を用いて全国小・中学生気管支喘息の有症率調査をおこなった．対象者は小学１，２年生および中学２，３年生を各都道府県それぞれ1,200名以上となるように抽出した．小・中学生の喘息期間有症率はそれぞれ13.9%，8.8%であった．小学生の喘息期間有症率は男子で有意に高い結果となった．アレルギー性鼻結膜炎，アトピー性皮膚炎の症状をあわせると，小中学生とも約３分の１がアレルギー疾患を有している結果となった．47都道府県別の喘息期間有症率は小中学生とも最大で約２倍の差が認められたが，ばらつきは少なかった．

食物蛋白誘発胃腸炎（Food protein-induced enterocolitis syndrome：FPIES）は非IgE依存性食物アレルギーの一病型であり，原因食物を摂取した1～4時間後に皮膚症状や呼吸器症状などのIgE依存性反応を伴わない繰り返す嘔吐で特徴づけられている．2017年の国際コンセンサスガイドライン公開により，世界各国でFPIESに関する報告が増えている．海外におけるFPIESの原因食品は，牛乳・米・魚が多く，鶏卵がそれに続いている．一方，日本ではこの数年で鶏卵，特に卵黄によるFPIESの患者が急激に増加しており，現在では原因食品として最も頻度が高い．このため，鶏卵FPIESの発症年齢，予後などの疫学面では日本を中心に解明が進んでいるが，原因抗原・感作経路・嘔吐の機序・免疫学的機序については不明な点が多い．診断の補助となる検査，安全で信頼性の高い食物経口負荷試験や長期管理の方法も確立されていない．今後これらが明らかにされることで，急増する鶏卵FPIES患者数に歯止めがかかることが期待される．

【背景・目的】牛乳特異的IgE抗体 (sIgE) が陽性化する新生児・乳児食物蛋白誘発胃腸症患者の牛乳アレルゲンコンポーネントの特徴を明らかにする.

Anaphylaxis is a severe allergic reaction that is rapid in onset and might cause death. Although wheezes, dyspnea or loss of consciousness are known to occur with severe allergic reactions with IgE-mediated food allergy, reports of apnea attack associated with IgE-mediated food allergy are rare. In this case, 9-year-old boy with IgE-mediated wheat allergy experienced apnea attack with strong desaturation after an immediate allergic reaction including erythema, abdominal pain, vomiting, and anaph