東北大学 · 医学
Saito教授の研究室は、小児におけるノロウイルスおよびサポウイルスの感染疫学に注目し、特に乳児期の反復感染とその型特異的免疫の形成を解明しています。母乳に存在する特異的抗体（IgA）が感染後の症状軽減に寄与する可能性を示し、母胎免疫の役割にも注目しています。これらの知見は、多価型を標的にする効果的なワクチン開発に不可欠な基盤を提供しています。
Figures are computed from collected data and may differ slightly.
Norovirus infection occurs early in life and children experience serial infections with multiple genotypes, suggesting genotype-specific immunity. An effective vaccine would have a substantial impact on morbidity, but may need to target multiple genotypes.
Sapovirus was frequently detected in children with AGE at the community level during the first 2 years of life. Serial sapovirus infections by multiple genotypes in a child suggest genotype-specific immunity from each infection, which needs to be taken into account for vaccine development.
Mothers with high positivity rates and titers of NV-IgA in breast milk had NV infected infants with reduced diarrheal symptoms. Antigenic relatedness to the genetic diversity of human norovirus was suggested.Funding National Institute of Allergy and Infectious Diseases, National Institute of Health: 1R01AI108695-01A1 and the Japan Society for the Promotion of Science (Fostering Joint International Research B):19KK0241.
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