Keio University · Medicine
Michiie Sakamoto 교수의 연구실은 간세포생식성암(HCC)의 면역 미세환경 분류, 종양 생물학적 특성과 유전적 변화의 상관관계, 그리고 비바이러스성 간세포암(Non-B, Non-C HCC)의 임상적 특성에 중점을 두고 있습니다. 특히 HCC의 면역상태 기반 분류와 병변의 파손 여부가 예후에 미치는 영향을 규명하며, 임상적 단계화의 보완적 접근을 모색하고 있습니다. 또한 일본 전국 대규모 간암 추적 조사 자료를 기반으로 한 장기적 임상 패턴 분석을 통해 진단 및 치료 전략의 개선을 도모하고 있습니다.
Figures are computed from collected data and may differ slightly.
The immune microenvironment of HCC can be classified into three immunosubtypes (Immune-high, Immune-mid, and Immune-low) with additional prognostic impact on histological and molecular classification of HCC. (Hepatology 2018).
The new models reflected the wide range of patho-biological features and genetic alterations that characterize human pancreatic cancer and may be used collectively or selectively as a markedly improved in vivo tool for preclinical and molecular studies of pancreatic cancer.
The present study suggested that tumor rupture itself had a negative impact on patient survival. However, its impact was not strong enough to cancel the effects of the other tumor-related parameters. Therefore, it may be appropriate to give additional stages to the baseline tumor staging in cases of ruptured HCC.
The findings of this nationwide survey indicated that patients with NBNC-HCC had a significantly lower risk of HCC recurrence than those with HBV-HCC and HCV-HCC.
In the 20th Nationwide Follow-up Survey of Primary Liver Cancer in Japan, data from 21 075 new patients and 40 769 previously followed patients were compiled from 544 institutions over a 2-year period from 1 January 2008 to 31 December 2009. Compared with the previous 19th survey, the population of patients with hepatocellular carcinoma (HCC) was older at the time of clinical diagnosis, included more female patients, included more patients with non-B non-C HCC, had smaller tumor diameters and mo
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