京都大学 · 生化学・遺伝学・分子生物学
Miho Inoue-Murayama教授の研究室では、行動遺伝学の分野に焦点を当て、ヒトや動物の性格・行動の遺伝的基盤を解明することを目的としています。主にニホンミツバチやニホンミツバチに近縁な鳥類(ニホンミツバチ)、サル類、イヌ、ニワトリなど多様な種をモデルに、ドーパミン・セロトニン系関連遺伝子の多様体と行動・感情の関連を分子遺伝学的手法を用いて解析しています。特に、性格特性(神経質さ、社会性、支配性)やストレス関連ホルモン(コルチゾール)との関連を、遺伝子型と行動評価・生理的指標の統合的解析によって明らかにしています。
Figures are computed from collected data and may differ slightly.
The recessive black plumage mutation in the Japanese quail (Coturnix japonica) is controlled by an autosomal recessive gene (rb) and displays a blackish-brown phenotype in the recessive homozygous state (rb/rb). A similar black coat color phenotype in nonagouti mice is caused by an autosomal recessive mutation at the agouti locus. An allelism test showed that wild type and mutations for yellow, fawn-2, and recessive black in Japanese quail were multiple alleles (*N, *Y, *F2, and *RB) at the same
The D4 dopamine receptor (D4DR) polymorphic region, which is possibly related to the personality trait known as novelty seeking in humans, was examined in 34 dogs from two breeds (Golden retriever and the Japanese indigenous breed, Shiba) by the polymerase chain reaction (PCR), and the DNA sequences of each allele were determined. The polymorphic region of the dog D4DR gene was composed of 39- and 12- base pair (bp) units, and four alleles (A-D) were identified based on the number and/or order o
We studied personality, subjective well-being, and hair cortisol level, in common marmosets Callithrix jacchus, a small, cooperatively breeding New World monkey, by examining their associations with one another and genotypes. Subjects were 68 males and 9 females that lived in the RIKEN Center for Life Science Technologies. Personality and subjective well-being were assessed by keeper ratings on two questionnaires, hair samples were obtained to assay cortisol level and buccal swabs were used to a
Various studies have shown the associations between differences in human behavioral traits and genetic polymorphism of neurotransmitter-related proteins such as receptors, transporters and monoamine oxidase. To clarify the genetic background of animal behavior, corresponding regions in animals have been analyzed. The study has been especially focused on primates, as the evolutionally closest animal to humans, and on dogs, as the socially closest animal to humans. In primates, polymorphisms were
Domestic fowl or chicken (Gallus gallus) and Japanese quail (Coturnix japonica) belong to the family Phasianidae. The exchange of marker information between chicken and quail is an important step towards the construction of a high-resolution comparative genetic map in Phasianidae, which includes several poultry species of agricultural importance. We tested chicken microsatellite markers to see if they would be suitable as genetic linkage markers in Japanese quail. Twenty-six per cent (31/120) of
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