Min Seok Baek

Progressive tau accumulation may be more prominent in ε4 carriers, particularly in the medial and lateral temporal cortices. ApoE ε4 allele has differential effects on the Aβ burden depending on the existing amyloidosis and may enhance vulnerability to progressive tau accumulation in the AD spectrum independent of Aβ.

Despite recent studies suggesting a declining incidence and prevalence of dementia on a global scale, epidemiologic results with respect to Alzheimer's disease (AD) are lacking due to the methodological limitations inherent to conducting large-scale cohort investigations of this topic. The aim of the current study was to investigate the incidence and prevalence of AD in Korea. We conducted a secondary analysis within the National Health Insurance System (NHIS) database, a unique resource that re

Full dynamics of biofluid biomarkers have been unknown in patients with Parkinson's disease (PD). Using data from 396 PD patients and 182 controls in the Parkinson's Progression Markers Initiative (PPMI) database, we estimated long-term temporal trajectories of CSF α-synuclein (α-syn), amyloid-β (Aβ), total tau (t-tau), phosphorylated tau (p-tau) and serum neurofilament light chain (NfL) by integrating function between the baseline levels and annual changes. At baseline, PD patients showed lower

This study aimed to investigate the risk and prognosis of Alzheimer's disease (AD) and vascular dementia (VaD) in patients with insomnia using the National Health Insurance Service database covering the entire population of the Republic of Korea from 2007 to 2014. In total, 2,796,871 patients aged 40 years or older with insomnia were enrolled, and 5,593,742 controls were matched using a Greedy digit match algorithm. Mortality and the rate of admission to a long-term care facility were estimated

Odor identification ability may serve as an important diagnostic biomarker in Alzheimer's disease (AD). The aim of the study is to investigate the contribution of A/T/N neuroimaging biomarkers to impaired odor identification ability in the Alzheimer's disease spectrum. In 127 participants, we compared A/T/N neuroimaging biomarkers between normosmia and hyposmia groups, and performed correlation analysis between the biomarkers and Cross-Cultural Smell Identification Test (CCSIT) scores. Additiona

We investigated the relationship between hippocampal subfield volumes and cortical amyloid-beta (Aβ) deposition in Alzheimer’s disease (AD). Fifty participants (11 cognitively unimpaired [CU], 10 with mild cognitive impairment [MCI], and 29 with AD) who underwent 18F-florbetaben positron emission tomography, magnetic resonance imaging, and neuropsychological tests were enrolled. The hippocampal subfield volumes were obtained using an automated brain volumetry system with the Winterburn atlas and

Dyskinesia hyperpyrexia syndrome is a rare medical emergency in Parkinson's disease. It is characterized by continuous dyskinesia associated with hyperthermia, rhabdomyolysis, and alteration of the mental state. We present the case of a 74-year-old woman who presented with recurrent dyskinesia hyperpyrexia syndrome. Although some provocation factors and clinical manifestations seem to be shared with parkinsonism hyperpyrexia syndrome, a clear distinction in management should be considered.

Abstract Background We investigated effects of apolipoprotein E (ApoE) ε4 genotype on Aβ and tau burden and their longitudinal changes in Alzheimer’s disease spectrum. Method Among 272 individuals who underwent PET scans ( 18 F‐florbetaben for Aβ and 18 F‐flortaucipir for tau), and ApoE genotyping, 187 individuals completed 2‐year follow up PET scans. After correcting for partial‐volume effect, we compared the SUV ratio (SUVR) for Aβ and tau burden between ε4+ and ε4‐ groups. By using a linear m

The purpose of this study is to investigate the risk of incidental Alzheimer's disease(AD) and vascular dementia (VD) in insomnia patients using the National Health Insurance Service (NHIS) database of the entire population of South Korea from 2007 to 2014. We examined the relationship between insomnia and the risk of dementia including mortality and a long-term care facility admission of dementia patients, as well as the interaction between insomnia and known cardiovascular risks through subgro

Background : Acute superior mesenteric artery occlusion is a life-threatening disease that often has nonspecific symptoms. However, it should be suspected in those with known risk factors such as atrial fibrillation, cardiac thrombus or cardiac valvular disease. \n\nCase Report : We reported two cases of acute thromboembolic occlusions of superior mesenteric artery that developed in acute cerebral infarction patients with confirmed atrial fibrillation. \n\nConclusions : Nonspecific symptoms of a

Abstract Background To investigate the effect of onset‐age on the baseline and longitudinal changes in A/T/N imaging biomarkers in the Alzheimer’s disease (AD) spectrum. Method 71 Aβ‐positive cognitively impaired (CI+) individuals and 67 Aβ‐negative cognitively unimpaired (CU‐) individuals completed longitudinal two PET scans ( 18 F‐florbetaben for Aβ and 18 F‐flortaucipir for tau) and magnetic resonance (MR) imaging studies with a mean follow‐up duration of two years. Based on the onset‐age of