Sungkyunkwan University · 環境科学
Professor Min-Chul Lee's research lab specializes in aquatic toxicology and environmental epigenetics, focusing on the impacts of environmental pollutants and nutritional factors on lipid metabolism and aging in marine invertebrates, particularly the rotifer *Brachionus koreanus*. The lab investigates molecular mechanisms underlying metabolic regulation, including sirtuin signaling and nuclear receptor pathways (e.g., RXR), under conditions of caloric restriction and exposure to obesogens like tributyltin (TBT). Their work integrates ecotoxicological assessments with molecular biology, transcriptomics, and lipidomic analyses to understand how environmental stressors affect life history traits and metabolic health. The lab also employs in silico modeling to predict molecular interactions, enhancing mechanistic insights into pollutant toxicity.
Figures are computed from collected data and may differ slightly.
In this study, we evaluated accumulation and adverse effects of ingestion of microplastics in the monogonont rotifer (Brachionus koreanus). The dependence of microplastic toxicity on particle size was investigated by measuring several in vivo end points and studying the ingestion and egestion using 0.05-, 0.5-, and 6-μm nonfunctionalized polystyrene microbeads. To identify the defense mechanisms activated in response to microplastic exposure, the activities of several antioxidant-related enzymes
Microplastic pollution causes a major concern in the marine environment due to their worldwide distribution, persistence, and adverse effects of these pollutants in the marine ecosystem. Despite its global presence, there is still a lack of information on the effect of microplastics on marine organisms at the molecular level. Herein we demonstrated ingestion and egestion of nano- (0.05 μm) and micro-sized (0.5 and 6 μm) polystyrene microbeads in the marine copepod Paracyclopina nana, and examine
To examine the interrelationship of aging extension and modification of lipid metabolism under chronic caloric restriction (CCR; reduced concentration of the green algae Tetraselmis suecica) in the monogonont rotifer Brachionus koreanus, we assessed life cycle parameters, fatty acid composition, and expression of sirtuin and genes related to lipid metabolism. B. koreanus in the 5% T. suecica group showed an increased life span but decreased reproduction. Based on this finding, we chose 5% T. sue
To examine how tributyltin (TBT), a model obesogen, affects the lipid metabolism in the marine rotifer Brachionus koreanus, we carried out life-cycle studies and determined the in vitro and in silico interactions of retinoid X receptor (RXR) with TBT, the transcriptional levels of RXR and lipid metabolic genes, and the fatty acid content. The lethal concentration 10% (LC10) was determined to be 5.12 μg/L TBT, and negative effects on ecologically relevant end points (e.g., decreased lifespan and
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