慶應義塾大学 · 医学
Oya教授の研究室は、がんの病態メカニズムと予後予測のためのバイオマーカーの同定を柱としています。特に、凝固・炎症反応関連マarkers（D-短鎖線維状タンパク質、CRP、NF-κB、AhRなど）が腫瘍の進行や予後に与える影響を分子メカニズムから解明しています。消化器・泌尿器がんにおける腫瘍微小環境の炎症反応とがんの悪性度の関連を、臨床的・分子的アプローチで統合的に研究しています。
Figures are computed from collected data and may differ slightly.
Elevated plasma D-dimer levels in patients with colorectal cancer are associated with relatively advanced tumor stage and short postoperative survival after curative resection. It appears that measurement of preoperative D-dimer level would be useful in the preoperative diagnosis of tumor stage and prediction of postoperative survival.
Although an aggressive phenotype of renal cell carcinoma (RCC) is known to frequently be associated with inflammatory paraneoplastic syndrome including serum C-reactive protein (CRP) elevation, the molecular mechanism underlying this clinical phenomenon as well as what yields the malignant phenotype leading to the progression of RCC has yet to be elucidated. Based on the increased level of inflammatory cytokines such as interleukin-6 in advanced cases of RCC, a cytokine-inducible transcription f
Aryl hydrocarbon receptor (AhR) and the activation of the AhR pathway are involved in xenobiotic-induced toxicity and carcinogenesis. Although xenobiotics, such as cigarette smoke, contribute to the development of urothelial carcinoma (UC), the relationship between AhR and UC is unclear. In the present study, we investigated AhR expression in 209 patients with upper urinary tract UC. The nuclear expression of AhR was significantly associated with histological grade, pathological T stage, lymphov
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