慶應義塾大学 · 医学
横木直久教授の研究室は、消化器内視鏡治療分野に焦点を当て、特に胃がんの内視鏡的治療技術の開発と標準化を主眼としています。特に、エンドスコープを用いた粘膜下層剥離術（ESD）の新技術開発や、術後の傷跡形成・治癒過程の解明が進んでいます。また、難易度の高い部位（例：十二指腸）におけるESD技術の応用や、遺伝子多型と薬物毒性の関連性に関する研究も実施しており、臨床的応用に直結する革新的な研究が特徴です。
Figures are computed from collected data and may differ slightly.
Background: Although the strip biopsy method and aspiration method are popular endoscopic mucosal resection techniques for its convenience and reliability, they have limitations in resectable tumor size and location. Endoscopic submucosal dissection techniques using the diathermic needle knife or the insulated‐tip diathermic knife have been introduced to overcome this disadvantage, but they have high risks for bleeding and perforation. Therefore, we have developed a new endoscopic submucosal dis
Further development of the technique, devices and training systems will promote worldwide standardization of ESD.
Background: Due to the remarkable progress of endoscopic resection techniques, endoscopic submucosal dissection (ESD) has been widely performed for larger mucosal tumors that would result in large artificial ulcers. The healing process of peptic ulcers has been previously studied in detail; however, no precise investigation for artificial ulcers after ESD has been reported. To confirm the validity of the treatment from the aspect of wound healing, we aimed to clarify the healing process of large ga
The authors investigated whether high-dose methotrexate-induced toxicity differed according to the presence of methylenetetrahydrofolate reductase (MTHFR) or reduced folate carrier 1 (RFC1) genetic polymorphism. The authors studied 15 children with acute lymphoblastic leukemia or lymphoblastic lymphoma who were treated using protocols that included high-dose methotrexate (3.0 g/m), for an overall total of 43 courses. Methotrexate-induced toxicities and the plasma methotrexate concentrations were
Duodenal endoscopic submucosal dissection (ESD) is difficult due to insufficient mucosal elevation, because of the coarse submucosal layer [1]. We report on the "water pressure method" for duodenal ESD.
ABSTRACT Scheduled piecemeal resection has been actively conducted for granular type laterally spreading tumor (LST‐G) in Japan, as long as a definite preoperative diagnosis is made. However, en bloc resection is desirable for depressed lesions (e.g. IIc lesion) as well as non‐granular type laterally spreading tumor (LST‐NG) since they have considerable high risk for submucoasl invasion and require precise histopathological evaluation. Endoscopic submucosal dissection (ESD) has been developed fo
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