大阪大学 · 医学
ミヨシ教授の研究室は、がんの発症機構とがん細胞の多能性特性に着目し、特に消化器がんにおける遺伝子再プログラミングやエピジェネティクスのダイナミクスを解明することを主眼としています。iPS細胞関連因子の導入ががん細胞に未分化状態を誘導するメカニズムや、DNAメチル化解体の動態、がんの予後予測マーカー（TRIB3、SCRN1、ANXA9など）の同定を進めています。がんの治療戦略の高度化に貢献する、がんの幹細胞的特性とエピジェネティクスの交差点を研究しています。
Figures are computed from collected data and may differ slightly.
Although cancer is a disease with genetic and epigenetic origins, the possible effects of reprogramming by defined factors remain to be fully understood. We studied the effects of the induction or inhibition of cancer-related genes and immature status-related genes whose alterations have been reported in gastrointestinal cancer cells. Retroviral-mediated introduction of induced pluripotent stem (iPS) cell genes was necessary for inducing the expression of immature status-related proteins, includ
These data strongly suggest the usefulness of TRIB3 as a marker for predicting the prognosis of CRC patients, showing a basis for the development of effective treatments for CRC.
The genome-wide depletion of 5-methylcytosines (5meCs) caused by passive dilution through DNA synthesis without daughter strand methylation and active enzymatic processes resulting in replacement of 5meCs with unmethylated cytosines is a hallmark of primordial germ cells (PGCs). Although recent studies have shown that in vitro differentiation of pluripotent stem cells (PSCs) to PGC-like cells (PGCLCs) mimics the in vivo differentiation of epiblast cells to PGCs, how DNA methylation status of PGC
In patients with T4 esophageal cancer who receive CRT followed by curatively resection, myelogenic chemotoxicity is a significant prognostic factor.
Annexin A9 (<i>ANXA9</i>) is involved with the interaction with membrane phospholipids in a Ca<sup>2+</sup>-dependent manner. A previous study has shown that <i>ANXA9</i> expression is associated with bone metastasis in breast cancer, whereas its significance in colorectal cancer (CRC) is unknown. The present study was comprised of 100 patients who underwent surgery for CRC. The correlation between gene expression and the clinical parameters of the patients was assessed. Patients with high <i>AN
The present data strongly suggest that SCRN1 expression is a prognostic factor in CRC patients.
The submucosal invasion depth predicts prognosis in early colorectal cancer. Although colorectal cancer with shallow submucosal invasion can be treated via endoscopic resection, colorectal cancer with deep submucosal invasion requires surgical colectomy. However, accurately diagnosing the depth of submucosal invasion via endoscopy is difficult. We developed a tool to diagnose the depth of submucosal invasion in early colorectal cancer using artificial intelligence. We reviewed data from 196 pati
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