東京大学 · 医学
Ryosuke Tateishi教授の研究室は、肝細胞癌（HCC）の治療成績と予後予測に関する包括的研究を推進しています。特に射頻電波焼灼術（RFA）の長期的有効性や、体組成（サルコペニア、内臓脂肪蓄積など）が予後に与える影響を解明しており、BMIに頼らない個別化医療の基盤を築いています。また、日本人特有のHCCリスク要因や腫瘍マーカーの予後予測能についても、臨床的・疫学的アプローチで革新的な知見を提供しています。
Figures are computed from collected data and may differ slightly.
The authors confirmed the safety and efficacy of RFA for HCC in a large-scale series and long-term prognosis was satisfactory.
Sarcopenia, IMF deposition, and visceral adiposity independently predict mortality in patients with HCC. Body composition rather than BMI is a major determinant of prognosis in patients with HCC.
The Tokyo score is a simple system which provides good prediction of prognosis for Japanese patients with HCC requiring radical therapy.
The proportion of HCC patients with non-viral etiologies continues to increase in Japan. Lifetime total amount of alcohol consumption may be a risk factor.
Most cases of non-B, non-C HCC are related to lifestyle factors, including obesity and diabetes. Slightly overweight patients showed the best prognosis.
Three tumor markers for hepatocellular carcinoma (HCC) are available in daily practice in Japan: alpha-fetoprotein (AFP), des-gamma-carboxy prothrombin (DCP), and lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3). To elucidate the predictability of these tumor markers on HCC recurrence after curative ablation, we enrolled 416 consecutive patients with naïve HCC who had been treated by percutaneous ablation at our department from July 1997 to December 2002. Tumor marker le
Using the National Oceanic & Atmospheric Administration (NOAA) National Aeronautics & Space Administration (NASA) Pathfinder Land dataset (PAL data) from 1982–2000, vegetation phenology (onset, peak and offset) was defined and analysed with climate data. In areas of precipitation-dependent phenology such as Central Africa, it was found that Normalized Difference Vegetation Index (NDVI) is affected approximately 20–40 days after the occurrence of precipitation, depending on land cover types. In a
Poor differentiation degree was the risk factor of neoplastic seeding after RFA for HCC. The surrogate markers for poor differentiation degree were larger tumor size and elevated tumor marker levels. Indication for RFA should be carefully considered for HCC patients under these conditions.
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