Sungkyunkwan University · 医学
Professor Sang Eun Yoon's research lab focuses on translational and clinical oncology, with a strong emphasis on understanding the molecular and immunological mechanisms underlying lymphomas, particularly T-follicular helper (Tfh)-derived lymphomas and primary central nervous system lymphoma (PCNSL). The lab investigates the role of the gut microbiome in modulating chemotherapy response and disease progression in diffuse large B-cell lymphoma (DLBCL), and explores biomarkers such as circulating tumor DNA (ctDNA) for improved monitoring and prognosis prediction. Additionally, the lab examines clinical predictors, including tumor laterality and molecular subtypes, to refine treatment strategies in colorectal and lymphoid malignancies.
Figures are computed from collected data and may differ slightly.
Samsung Biomedical Research Institute.
Other TFH lymphomas appear to be a rare disease entity around one-quarter in nodal lymphomas of T follicular helper (Tfh) cell origin. Their less aggressive clinical feature than we did not expect is utterly different from PTCL-NOS and AITL. On the other hand, other TFH lymphomas share some characteristics, such as the cell of origin, a more common TBX21 subtype, and genetic variation such as RAS family mutation and epigenetic regulators, with AITL.
The gut microbiome influences cancer development and the efficacy and safety of chemotherapy but little is known about its effects on lymphoma. We obtained stool samples from treatment-naive, newly diagnosed patients with diffuse large B-cell lymphoma (DLBCL) (n = 189). We first performed 16S ribosomal RNA gene sequencing (n = 158) and then conducted whole-genome shotgun sequencing on additional samples (n = 106). We compared the microbiome data from these patients with data from healthy control
The plasma ctDNA mutation analysis still has limited value for surveillance and predicting treatment outcomes of PCNSL because the detection efficiency was lower than other systemic lymphomas. Thus, analytical platforms should be improved to overcome anatomical hurdles associated with PCNSL.
Recently, the sidedness of the primary tumor (right versus left) has been investigated for its ability to prognosticate and predict outcomes. We evaluated the effect of regorafenib based on KRAS mutation status and the sidedness of the primary tumor in patients with metastatic colorectal cancer (mCRC). We analyzed 135 patients with refractory metastatic colorectal cancer (mCRC) being treated with regorafenib at Samsung Medical Center, between January 2014 and January 2018. Primary tumors origina
The treatment outcome of patients with the Asian variant of IVLBCL is still not satisfactory. The prediction of CNS involvement based on the clinical features including CNS-IPI score might not serve to identify patients at high risk of CNS involvement, either. Thus, more effective strategies for diagnosis and treatment should be developed.
Epstein-Barr virus (EBV) positivity in diffuse large B cell lymphoma (DLBCL) provokes a critical oncogenic mechanism to activate intracellular signaling by LMP1. LMP1 specifically mimics the role of BTK-dependent B cell receptor. Therefore, a trial considering RCHOP therapy along with ibrutinib (I-RCHOP) in combination was conducted among patients with EBV-positive DLBCL. This study was an open-label, single-arm, prospective multicenter phase II clinical trial. Patients received 560 mg of ibruti
<b>Background:</b> Progression within 24 months after initiating treatment (POD24) is established as an unfavorable event predicting poor prognosis in patients with follicular lymphoma (FL). However, little is known about the impact of transformation on the outcome of FL patients with POD24 although transformation could be related to early progression and poor prognosis in FL patients. <b>Methods:</b> We investigated the occurrence of transformation and its association with POD24 in FL patients
<b>Background</b>: Gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC) is a heterogeneous disease in terms of embryonic origin, aggressiveness, prognosis, and genomic profiling. Data regarding the efficacy of etoposide and cisplatin (EP) as a standard treatment of the primary tumor site in GEP-NEC are limited. <b>Materials and Methods</b>: We analyzed 64 patients with histopathologically confirmed metastatic GEP-NEC who received EP at Samsung Medical Center, Seoul, Korea, between January 2
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