Korea University · 情報科学
Professor Sangkyun Lee's research lab specializes in interdisciplinary studies at the intersection of bioorganic chemistry, neuroscience, and computational data science. The lab investigates natural compounds—particularly monoterpenoids—for their pesticidal and phytotoxic properties, focusing on their potential as eco-friendly pest control agents. Concurrently, the lab explores advanced machine learning and signal processing techniques, especially support vector machines and multivariate analysis, to decode brain activity and understand cerebral reorganization during skill learning. Additionally, the lab develops efficient computational algorithms, particularly for large-scale and streaming data, with applications in compressed sensing and GPU-accelerated computing.
Figures are computed from collected data and may differ slightly.
Acute toxicities of 34 naturally occurring monoterpenoids were evaluated against 3 important arthropod pest species; the larva of the western corn rootworm, Diabrotica virgifera virgifera LeConte; the adult of the twospotted spider mite. Tetranychus urticae Koch; and the adult house fly. Musca domestica L. Potential larvicidal or acaricidal activities of each monoterpenoid were determined by topical application, leaf-dip method, soil bioassay, and greenhouse pot tests. Phytotoxicity was also tes
The authors demonstrate the application of multivariate methods for assessing cerebral reorganization during the learning of volitional control of local brain activity. The findings provide insight into mechanisms of training-induced learning techniques for rehabilitation. The authors anticipate that future studies, specifically designed with this hypothesis in mind, may be able to construct a universal index of cerebral reorganization during skill learning based on multiple similar criteria acr
Iterative methods that calculate their steps from approximate subgradient directions have proved to be useful for stochastic learning problems over large and streaming data sets. When the objective consists of a loss function plus a nonsmooth regularization term, the solution often lies on a low-dimensional manifold of parameter space along which the regularizer is smooth. (When an l1 regularizer is used to induce sparsity in the solution, for example, this manifold is defined by the set of nonz
Sixteen natural monoterpenoids and 6 synthetic derivatives were selected for study of larvicidal activity and growth inhibitory effect against the European corn borer, Ostrinia nubilalis (Hübner). For this study, 2 different dietary exposure bioassays were used: compounds applied on the diet surface (on-diet), and compounds incorporated into the diet (in-diet). Most of the monoterpenoid compounds showed some degree of larvicidal activity in both bioassay procedures after a 6-d exposure period. A
There is a growing interest in using support vector machines (SVMs) to classify and analyze fMRI signals, leading to a wide variety of applications ranging from brain state decoding to functional mapping of spatially and temporally distributed brain activations. Studies so far have generated functional maps using the vector of weight values generated by the SVM classification process, or alternatively by mapping the correlation coefficient between the fMRI signal at each voxel and the brain stat
Several highly effective algorithms that have been proposed recently for compressed sensing and image processing applications can be implemented efficiently on commodity graphical processing units (GPUs). The properties of algorithms and application that make for efficient GPU implementation are discussed, and computational results for several algorithms are presented that show large speedups over CPU implementations.
Cortical neuropil modulations recorded by calcium imaging reflect the activity of large aggregates of axo-dendritic processes and synaptic compartments from a large number of neurons. The organization of this activity impacts neuronal firing but is not well understood. Here we used <i>in vivo</i> 2-photon imaging with Oregon Green Bapta (OGB) and GCaMP6s to study neuropil visual responses to moving gratings in layer 2/3 of mouse area V1. We found neuropil responses to be strongly modulated and m
Feature selection is an important task in machine learning, reducing dimensionality of learning problems by selecting few relevant features without losing too much information. Focusing on smaller sets of features, we can learn simpler models from data that are easier to understand and to apply. In fact, simpler models are more robust to input noise and outliers, often leading to better prediction performance than the models trained in higher dimensions with all features. We implement several fe
Iterative methods that calculate their steps from approximate subgradient directions have proved to be useful for stochastic learning problems over large and streaming data sets. When the objective consists of a loss function plus a nonsmooth regularization term whose purpose is to induce structure in the solution, the solution often lies on a low-dimensional manifold of parameter space along which the regularizer is smooth. (When an l1 regularizer is used to induce sparsity in the solution, for
Convolutional neural networks (CNNs) have achieved tremendous success in solving complex classification problems. Motivated by this success, there have been proposed various compression methods for downsizing the CNNs to deploy them on resource-constrained embedded systems. However, a new type of vulnerability of compressed CNNs known as the adversarial examples has been discovered recently, which is critical for security-sensitive systems because the adversarial examples can cause malfunction o
A network intrusion detection (NID) system plays a critical role in cybersecurity. However, the existing machine learning-based NID research has a vital issue that their experimental settings do not reflect real-world situations where unknown attacks are constantly emerging. In particular, their train and test sets are from a single data set, which inevitably overestimates the detection power since all test attack types are known in training, and test cases will have similar characteristics to t
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