東京大学 · 医学
宮脇颯教授の研究室は、脳血管障害、特に閉塞性動脈症に関連する遺伝子変異の解明を柱としています。特にRNF213遺伝子のc.14576G>A変異が、日本人群中で特徴的な脳動脈硬化性虚血性脳症（ICASO）の原因となる可能性を示しており、新たな疾患実体の提案を進めています。また、脳虚血後の神経変性機構や、心臓合併症を伴う頸動脈手術のリスク管理についても臨床的・病理的アプローチを併用した研究を展開しています。
Figures are computed from collected data and may differ slightly.
A particular subset of patients with various phenotypes of ICASO has a common genetic variant, RNF213 c.14576G>A, indicating that RNF213 c.14576G>A variant is a high-risk allele for ICASO.
The present study indicates that a particular subset of Japanese patients with non-MMD ICASO has a genetic variant associated with MMD. Therefore, we propose the existence of a new entity of ICASO caused by the c.14576G>A variant in RNF213.
This study indicates that RNF213 c.14576G>A is associated with negative remodeling of ICAS.
Histopathology and IMS can provide comprehensive and complementary information on cell death mechanisms in the hippocampal CA1 after global ischemia. IMS provided novel data on molecular changes in phospholipids immediately after TGI. Increased level of PC (diacyl-16:0/22:6) in the pyramidal cell layer of hippocampal CA1 prior to the histopathological change may represent an early step in delayed neuronal death mechanisms.
Ischemic cardiac complication is one of the major perioperative complications of surgical treatment for cervical carotid stenosis, carotid endarterectomy (CEA), and carotid artery stenting (CAS), and may greatly affect surgical outcome, especially in elderly patients aged ≥ 80 years. We retrospectively analyzed the records of 259 patients (34 patients aged ≥ 80 years) treated by CEA and 61 patients (12 patients aged ≥ 80 years) treated by CAS at Aizu Chuo Hospital from January 2000 to September
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