京都大学 · 物理学・天文学
Satoshi Yamada教授の研究室は、合成生物学的手法を用いたアミノ酸のバイオプロダクション、特にL-システインの高効率生産を主な研究テーマとしています。遺伝子改変大腸菌を用いた代謝工学的アプローチにより、代謝経路の制御と不要な分解酵素の不活性化を組み合わせ、工業的応用に適したL-システインの過剰産生を実現しています。また、輸送体の同定を通じて細胞内のアミノ酸流出を制御する新規戦略の開発にも注力しています。
Figures are computed from collected data and may differ slightly.
L-cysteine is an important amino acid in terms of its industrial applications. We previously found a marked production of L-cysteine from glucose in recombinant Escherichia coli cells expressing an altered cysE gene encoding feedback inhibition-insensitive serine acetyltransferase. Also, a lower level of cysteine desulfhydrase (CD) activity, which is involved in L-cysteine degradation, increased L-cysteine productivity in E. coli. The use of an L-cysteine efflux system could be promising for bre
Abstract We perform a systematic X-ray spectroscopic analysis of 57 local luminous and ultraluminous infrared galaxy systems (containing 84 individual galaxies) observed with the Nuclear Spectroscopic Telescope Array and/or Swift/BAT. Combining soft X-ray data obtained with Chandra, XMM-Newton, Suzaku, and/or Swift/XRT, we identify 40 hard (>10 keV) X-ray–detected active galactic nuclei (AGNs) and constrain their torus parameters with the X-ray clumpy torus model XCLUMPY. Among the AGNs at z
Fusion of vesicular stomatitis virus with some cells (HELR 66, KB, and human erythrocytes, both intact and trypsinized) and liposomes made of various natural and synthetic lipids was studied with spin-labeled phospholipid. Binding of virus was assayed separately with radiolabeled and spin-labeled virus. Binding to cells and liposomes was small at neutral pH but enhanced at acidic pHs. Fusion with cells and liposomes was negligibly small at neutral pH but greatly activated at acidic pHs lower tha
Abstract We conduct hard X-ray to radio multiwavelength spectral energy distribution (SED) decomposition for 57 local luminous and ultraluminous infrared galaxies observed with the Nuclear Spectroscopic Telescope Array and/or Swift/Burst Alert Telescope in the GOALS sample. We modify the latest SED-fitting code X-CIGALE by implementing the infrared (IR) CLUMPY model, allowing us to conduct the multiwavelength study with the X-ray torus model XCLUMPY self-consistently. Adopting the torus paramete
Abstract As an inaugural investigation under the X-ray Winds In Nearby-to-distant Galaxies (X-WING) program, we assembled a data set comprising 132 active galactic nuclei (AGNs) spanning redshifts z ∼ 0–4 characterized by blueshifted absorption lines indicative of X-ray winds. Through an exhaustive review of previous research, we compiled the outflow parameters for 583 X-ray winds, encompassing key attributes such as outflow velocities ( V out ), ionization parameters ( ξ ), and hydrogen column
Abstract We study “buried” active galactic nuclei (AGNs) almost fully covered by circumnuclear material in ultra/luminous infrared galaxies (U/LIRGs), which show weak ionized lines from narrow-line regions. Employing an indicator of a [O iv ] 25.89 or [Ne v ] 14.32 μ m line to 12 μ m AGN luminosity ratio, we find 17 buried AGN candidates that are [O iv ]-weak ( L [O IV ] / L 12,AGN ≤ −3.0) or [Ne v ]-weak ( L [Ne V] / L 12,AGN ≤ −3.4) among 30 AGNs in local U/LIRGs. For the [O iv ]-weak AGNs, we
Open papers in the app to read, cite, and organize with AI.