名古屋大学 · 医学
Satoshi Yanagisawa教授の研究室は、心房細動（AF）と心不全を合併した患者を対象に、心電図的・神経humoral的バイオマーカーの意義を解明する研究を推進しています。特に、赤血球分布幅（RDW）や脳ナトリウム利尿ペプチド（BNP）、心電活動の変動（HRV・PWD）といった非侵襲的指標が、再発予後や神経内分泌系制御に与える影響を詳細に解析しています。また、カテーテルアブレーション後の生理的変化や、ペースメーカー治療（CRT）への反応性に関連する背景因子の同定にも注力しています。
Figures are computed from collected data and may differ slightly.
High RDW is an independent predictor for the recurrence of AF and major adverse events in patients with HF after catheter ablation. RDW is a potential noninvasive marker in AF patients complicated with HF. (Circ J 2016; 80: 627-638).
The periprocedural bleeding risk during the use of uninterrupted oral anticoagulants was higher in the elderly group than in the younger group. This area needs more attention for these patients in whom caution is required.
The reverse dynamics of PWD after initial shortening directly following ablation were significantly associated with PV reconnection.
Plasma BNP levels decreased significantly with successful catheter ablation of AF in patients with impaired LVEF. The decrease in BNP levels might be associated with early recovery of cardiac function and subsequent maintenance of sinus rhythm at follow-up.
Greater response to biventricular pacing occurs more frequently in patients with consistent right ventricular pacing, lack of prior history of ventricular arrhythmia, and smaller LAD. An association between patient background characteristics and a super-response to CRT was also identified.
Changes in HRV parameters following ablation were similarly observed in both the groups. EAT volume on the LA-PV junction is helpful for interpretation of VR occurrence and ANS modulation.
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