Seongmin Park

Although several somatic single nucleotide variations in histone H3.3 have been investigated as cancer drivers, other types of aberration have not been well studied. Here, we demonstrate that overexpression of H3F3A, encoding H3.3, is associated with lung cancer progression and promotes lung cancer cell migration by activating metastasis-related genes. H3.3 globally activates gene expression through the occupation of intronic regions in lung cancer cells. Moreover, H3.3 binding regions show char

Considering its specific effects on cell cycle-related E2F target genes and its significant association with the prognosis of lung cancer patients, we suggest that the transcriptional regulation of EPEL through E2F target genes is potentially a target for the development of novel therapeutic strategies for lung cancer patients.

Long intergenic non-coding RNAs (lincRNAs) have historically been ignored in cancer biology. However, thousands of lincRNAs have been identified in mammals using recently developed genomic tools, including microarray and high-throughput RNA sequencing (RNA-seq). Several of the lincRNAs identified have been well characterized for their functions in carcinogenesis. Here we performed RNA-seq experiments comparing gastric cancer with normal tissues to find differentially expressed transcripts in int

The combination of long-range interacting HOXA9 and HOXA10 promoter CpGs predicted the survival of breast cancer patients, providing a comprehensive and novel approach for discovering new methylation markers.

The unexpected formation of gas hydrates during production and transportation processes in petroleum industries is known as a serious problem. To deal with this problem, the oil and gas industry has been searching for hydrate inhibitors that have great performance and cost effectiveness. Recently, ionic liquids (ILs) have been suggested as novel hydrate inhibitors that are able to act in both thermodynamic and kinetic ways (so-called dual-function inhibitors). In this paper, we suggest a non-ion

Multiple H2 occupancy in confined cages has been explored for the purpose of enhancing storage capacity. Furthermore, balancing the formation pressure with high storage capacity is one of the most significant factors. Here, we demonstrate the use of binary (LGM + N2) hydrates to capture hydrogen clusters under relatively mild conditions, even observing double H2 occupancy in small cages. The cage occupancy and structures of hydrates were identified by the Raman spectroscopic analysis and high-re

Rational structure–mechanism-based strategies for identifying small molecules that are able to control multiple pathological targets in Alzheimer's disease are established, with an example of developing a promising multi-target-directed flavonoid.

The stability of hydrate frameworks is influenced by guest molecules capable of hydrogen bonding with surrounding water molecules. Four remarkable features from the ammonium fluoride incorporation into a crystalline hydrate matrix provide important information on the thermodynamic stability, formation kinetics, structural characteristics, and molecular behavior in clathrate hydrate systems.

The misfolding and aggregation of amyloid-β (Aβ) peptides are histopathological features found in the brains of Alzheimer's disease (AD). To discover effective therapeutics for AD, numerous efforts have been made to control the aggregation of Aβ species and their interactions with other pathological factors, including metal ions. Metal ions, such as Cu(II) and Zn(II), can bind to Aβ peptides forming metal-bound Aβ (metal-Aβ) complexes and, subsequently, alter their aggregation pathways. In parti

The structures and the guest-host distributions of iso-propylamine (i-PA) and n-propylamine (n-PA) hydrates with hydrogen as a secondary guest were identified by powder X-ray diffraction and Raman spectroscopic analysis. The structure of 11.1 mol% i-PA + H2 hydrate was identified to be hexagonal (space group P63/mmc) with a few unindexed diffraction peaks, while 5.6 mol% i-PA + H2 hydrate had a cubic structure (space group Fd3¯m). Similarly, the structure of 13.3 mol% n-PA + H2 hydrate was found

Aggregates of both metal‐free amyloid‐β (Aβ) and metal‐bound Aβ (metal–Aβ) are accumulated in the brain affected by Alzheimer's disease. To control metal‐free and metal‐bound Aβ species, chemical reagents capable of modulating their aggregation profiles have been developed. As an effort, the reactivity of natural products such as flavonoids with metal‐free Aβ and metal–Aβ has been investigated to identify their use as chemical reagents and structural features essential for such reactivity. This