東京大学 · 生化学・遺伝学・分子生物学
松永茂樹教授の研究室は、海洋生物、特に海綿から抽出される多様な生物活性を示すペプチド類を標的としており、主に非リボソーム的ペプチド合成によって生じる構造的多様性と生物学的機能の解明を進めています。特に、サイクリックペプチドやテトラミック酸糖エステルなど、自然界に存在する強力な細胞接着阻害性・抗真菌性・細胞毒性活性を示す新規天然物の同定・構造決定・作用機構解明を柱としています。また、これらの天然物の生合成経路や微生物由来の可能性についても探求しており、医薬品創出への応用可能性を視野に研究を展開しています。
Figures are computed from collected data and may differ slightly.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnatoxin-a(s), a potent anticholinesterase from Anabaena flos-aquaeShigeki Matsunaga, Richard E. Moore, Walter P. Niemczura, and Wayne W. CarmichaelCite this: J. Am. Chem. Soc. 1989, 111, 20, 8021–8023Publication Date (Print):September 1, 1989Publication History Published online1 May 2002Published inissue 1 September 1989https://pubs.acs.org/doi/10.1021/ja00202a057https://doi.org/10.1021/ja00202a057research-articleACS PublicationsRequest reuse permissi
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTheonellamide F. A novel antifungal bicyclic peptide from a marine sponge Theonella spShigeki Matsunaga, Nobuhiro Fusetani, Kanehisa Hashimoto, and Markus WalchliCite this: J. Am. Chem. Soc. 1989, 111, 7, 2582–2588Publication Date (Print):March 1, 1989Publication History Published online1 May 2002Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/ja00189a035https://doi.org/10.1021/ja00189a035research-articleACS PublicationsRequest reuse per
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTheonellamides A-E, cytotoxic bicyclic peptides, from a marine sponge Theonella sp.Shigeki Matsunaga and Nobuhiro FusetaniCite this: J. Org. Chem. 1995, 60, 5, 1177–1181Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/jo00110a020https://doi.org/10.1021/jo00110a020research-articleACS PublicationsRequest reuse permissionsArticle Views697Altmetric-Citations10
An antimicrobial peptide, discodermin A, has been isolated from the marine sponge Discodermia kiiensis. The peptide showed antimicrobial activity as well as an inhibition of starfish embryo development. It appeared to be a tetradecapeptide consisting of D-Cys(O3H), L-Asp, L-MeGlu, L-Thr (2 moles), Sar, D-Pro, D-Ala, D- and L-t-Leu, D-Leu, L-Phe, D-Trp, and L-Arg.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAurantosides A and B: cytotoxic tetramic acid glycosides from the marine sponge Theonella spShigeki Matsunaga, Nobuhiro Fusetani, Yuko Kato, and Hiroshi HirotaCite this: J. Am. Chem. Soc. 1991, 113, 25, 9690–9692Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://pubs.acs.org/doi/10.1021/ja00025a054https://doi.org/10.1021/ja00025a054research-articleACS PublicationsRequest reuse
Marine sponges are shown to be abundant sources of bioactive peptides. Structurally they include linear peptides, peptide lactones, cyclic peptides, and depsipeptides, with number of residues ranging from two to 48. Some of them have highly modified structural features with nonproteinogenic amino acid or hydroxy acid residues, while others have those with minimal alterations from the common ribosomal peptides. The structural characteristics, biogenesis, biological activity, and the issue of prod
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