大阪大学 · 医学
Ohira教授の研究室では、立体的放射線治療（SRS・SBRT）における治療精度と計画最適化の向上を主眼としており、特にHyperArc（HA-VMAT）を用いた脳転移巣治療の生物学的的・物理的妥当性を検証しています。マルチ-leaf collimator（MLC）の設計差が照射計画の質に与える影響や、患者固定装置の位置決め精度、回旋誤差の影響についても詳細に分析しています。また、モンテカルロシミュレーションを用いた線束モデルの妥当性評価も進めており、臨床応用に即した高精度な治療技術の確立を目指しています。
Figures are computed from collected data and may differ slightly.
HA-VMAT plans provided significantly higher conformity and rapid dose falloff with respect to the C-VMAT plans.
The rotational setup errors for multiple brain metastases cases caused non-negligible underdosage for PTV and significant increases of V<sub>10Gy</sub> to V<sub>16Gy</sub> in SRS with HyperArc.
Encompass provided patient immobilization with adequate accuracy during HA treatment. The absolute maximum displacement IM was less than IM<sub>NC</sub> along the translational/rotational axes, and no statistically significant relationship between the treatment time and the IM was observed.
The narrower MLC provided significantly higher conformity, steeper dose gradient, and better normal tissue sparing.
The IME during STI using open- and full-face clamshell-style immobilization devices is approximately equal considering the adequate accuracy in patient positioning.
Our findings demonstrate the accuracy of the MC model using an adapted BEAMnrc component module for the Agility MLC.
Overall, the accuracy of iodine and HU values was higher for DLCT than for FKSCT.
The WDI estimated the RED and MD accurately and could form the basis for a new treatment planning approach for pancreatic cancer using contrast-enhancing agent.
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