Keio University · 医学
中島慎一郎教授の研究室は、てんかんやうつ病、統合失調症を代表とする精神疾患の神経生理学的メカニズムを、非侵襲的脳刺激法（TMS）と脳波計測（EEG）を組み合わせた先進的アプローチで解明しています。特に、皮膚の興奮性・抑制性のバランス（E/Iバランス）と神経可塑性の観点から、精神疾患の病態を神経回路レベルで解明することを目的としています。また、認知症の予防に寄与する脳予備能（brain reserve）のメカニズムについても教育歴の影響を検証しており、神経科学と臨床医学の融合的研究を推進しています。
Figures are computed from collected data and may differ slightly.
Major depressive disorder (MDD) is a mental illness with high socio-economic burden, but its pathophysiology has not been fully elucidated. Recently, the cortical excitatory and inhibitory imbalance hypothesis and neuroplasticity hypothesis have been proposed for MDD. Although several studies have examined the neurophysiological profiles in MDD using transcranial magnetic stimulation (TMS), a meta-analysis of TMS neurophysiology has not been performed. The objective of this study was to compare
Our findings suggest that education may exert a protective effect on total brain volume in the MCI stage but not in HC or AD. Thus, education may play an important role in preventing the onset of dementia through brain reserve in MCI.
Schizophrenia (SCZ) is a serious mental disorder, and its pathogenesis is complex. Recently, the glutamate hypothesis and the excitatory/inhibitory (E/I) imbalance hypothesis have been proposed as new pathological hypotheses for SCZ. Combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) is a non-invasive novel method that enables us to investigate the cortical activity in humans, and this modality is a suitable approach to evaluate these hypotheses. In this study, we
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