Shinji Nishiwaki

A procedure to obtain a topology of an optimal structure considering flexibility is presented. The methodology is based on a mutual energy concept for formulation of flexibility and the homogenization method. A multi-objective optimization problem is formulated as an application of compliant mechanism design. Some examples of the design of compliant mechanisms for plane structures are presented. © 1998 John Wiley & Sons, Ltd.

Okadaic acid (OA) is a potent non-12-O-tetradecanoyl-phorbol-13-acetate (non-TPA) type tumor promoter on mouse skin. OA acts on cells through inhibiting the activity of protein phosphatases and results in the increase of phosphorylation of proteins. Seventeen OA derivatives were evaluated as possible tumor promoters by means of three biochemical tests: inhibition of specific [3H]OA binding to a particulate fraction of mouse skin containing protein phosphatases, inhibition of protein phosphatase

Abstract In vibration optimization problems, eigenfrequencies are usually maximized in the optimization since resonance phenomena in a mechanical structure must be avoided, and maximizing eigenfrequencies can provide a high probability of dynamic stability. However, vibrating mechanical structures can provide additional useful dynamic functions or performance if desired eigenfrequencies and eigenmode shapes in the structures can be implemented. In this research, we propose a new topology optimiz

Abstract Passive heat sinks cooled by natural convection are reliable, compact, and low‐noise. They are widely used in telecommunication devices, LEDs, and so forth. This work builds upon the recent advancements in fluid topology optimization (TO) to present a case study of two‐ and three‐dimensional optimum design and thermal modeling for the natural convection problems using a reaction–diffusion equation (RDE)‐based level‐set method. To this end, first, a high‐fidelity thermal‐fluid model is c