名古屋大学 · 生化学・遺伝学・分子生物学
Ueno教授の研究室は、視細胞および網膜内側側背縁核（VMH）におけるプロトンチャネルの機能解析を通じて、神経細胞の酸化ストレス応答や神経伝達メカニズムを解明しています。特に、網膜の光刺激に対する電気視細胞反応（ERG）の変化や、網膜手術後の内層網膜機能の微細な障害を評価するための客観的指標（PhNR）の応用にも注力しています。また、磁場が生物学的反応や燃焼反応に与える影響を、生体模倣的プロセスの理解を目的として実験的に探求しています。
Figures are computed from collected data and may differ slightly.
The photopic hill in the primate ERG results mainly from two factors: the reduction of the ON-component amplitude at higher intensities and the delay in the positive peak of the OFF-component at higher intensities.
The effects of magnetic fields on biological and chemical processes are investigated. Time-varying magnetic fields produce eddy currents which stimulate excitable tissues at low frequencies and give rise to thermal effects at high frequencies. Biological and chemical effects of static magnetic fields are poorly understood. The effects of magnetic fields on combustion of alcohol and hydrocarbons are studied to simulate in part the oxidation of organic matter in the living body. The combustion tem
Effects of magnetic fields on combustion and gas-flow were studied. Methane, propane and hydrogen gases were burned, and flames of these gases were exposed to gradient magnetic fields up to 1.6 T and 220 T/m. Flames bent so as to escape from magnetic fields of higher intensities. Apart from the combustion experiments, flows of gases such as carbon dioxide and oxygen were exposed to magnetic fields up to 2.2 T and 300 T/m. The flows of these gases with a flow velocity 20-140 ml/min were blocked o
1. The proton-gated current was investigated in freshly dissociated ventromedial hypothalamic (VMH) neurones from 4-week-old Wistar rats, under whole-cell configuration by the use of the 'concentration-clamp' technique which combines intracellular perfusion with the rapid exchange of external solution within 1-2 ms under a single-electrode voltage-clamp condition. 2. The proton-gated current increased in a sigmoidal fashion as extracellular pH (pHo) decreased. In external solution containing 2 m
These results suggest that there are some functional impairments in the inner retina after macular hole surgery, even though the patients did not show any reduction on subjective visual tests. The PhNR can be a useful clinical test to assess the inner retinal function objectively, before and after vitreoretinal surgery.
A sparse array of cone photoreceptors with significantly reduced density of the macula is one of the morphologic features of OMD.
Quantitative changes in the microvascular density might be useful for examining the pathophysiology of RP.
The significant correlations between the reduction in the thickness of the middle retinal layer and increase in the amplitude of the b-waves and OPs suggest that the improvement of macular function after ERM peeling is due to the decrease in the thickness of the middle retinal layer.
Possible influence of d.c. magnetic fields on the early embryonic development of frogs was studied. Embryos of African clawed toads, Xenopus laevis, were exposed to 1.0 T magnetic fields with different gradients of a range from 10 T/m to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> T/m either during cleavage to neurula stage, blastula to neurula stage, or neurula to tail bud stage. The developmental processes of embryos during and afte
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