慶應義塾大学 · 医学
Shotaro Chubachi教授の研究室は、慢性閉塞性肺疾患（COPD）をはじめとする呼吸器疾患の合併症、特に骨量減少や肺高血圧症、がんリスクのメカニズムを解明することを主眼としています。遺伝的要因（例：LRP5遺伝子多型）や画像所見、代謝異常（尿酸値）がCOPDの進行や合併症に与える影響を、大規模コhortを用いた疫学的・臨床的アプローチで解明しています。特にCOPD患者における骨・肺・循環器系の連関や、新型コロナウイルス感染症の病態と呼吸器疾患の関連についても積極的に研究を進めています。
Figures are computed from collected data and may differ slightly.
Abstract Background and objective Osteoporosis is an important systemic comorbidity of chronic obstructive pulmonary disease ( COPD ). However, neither its mechanisms nor its risk factors have been fully elucidated. With regard to genetic factors, low‐density lipoprotein receptor‐related protein 5 ( LRP 5 ) A 1330 V is known to be associated with osteoporosis in the general population, but the influence of this polymorphism in COPD is unknown. The aim of this study was to investigate the potenti
The severity of COPD exacerbation seemed to be temporally stable over 2 years, and even mild exacerbations adversely impacted the health-related quality of life of patients with COPD.
The presence of emphysema or interstitial abnormalities or a combination of both were independent predictors of lung cancer development in COPD patients. Furthermore, lung cancer most often developed in non-emphysematous areas or in interstitial abnormalities.
Patients hospitalized with COVID-19 with Omicron infections showed a lower incidence of critical outcomes than those with Delta infections, and COVID-19 vaccination may contribute to preventing respiratory failure.
In this study, we identified the clinical characteristics of COPD patients with PH detected by echocardiography. The presence of PH assessed by echocardiography was related to future COPD exacerbations and closely related to radiographical emphysema.
Abnormal serum uric acid levels or a history of hyperuricemia were significantly associated with COVID-19 severity in the Japanese cohort.
Open papers in the app to read, cite, and organize with AI.
