Yonsei University · 医学
Professor Suk Ho Byeon's research lab specializes in vitreoretinal diseases, with a focus on retinal cell survival mechanisms, retinal vascular pathology, and surgical outcomes in retinal disorders. The lab investigates molecular pathways—such as the VEGF-A/VEGFR2/PI3K/Akt axis—that influence retinal pigment epithelial (RPE) cell resilience under stress, particularly in conditions like age-related macular degeneration. They also explore imaging biomarkers, such as the middle limiting membrane sign and fluid accumulation patterns, to improve early detection of ischemic retinal damage. Additionally, the lab evaluates surgical techniques and postoperative complications, including hypotony and the effects of silicone oil tamponade on retinal structure and visual outcomes.
Figures are computed from collected data and may differ slightly.
Autocrine VEGF-A enhanced RPE cell survival under oxidative stress; the autocrine VEGF-A/VEGF-R2/PI3K/Akt pathway is involved. Neutralization of VEGF-A signaling, as in eyes with age-related macular degeneration, may influence RPE cell survival.
Though certain problems exist during and after surgeries using TSV, this system is both convenient and safe for various vitreoretinal procedures.
A prominent middle limiting membrane sign is a useful indicator of acute ischemic retinal damage, especially in cases showing subtle or resolved retinal opacities before the onset of atrophic changes.
Based on the concept of the fluid conductivity barrier, we revealed a correlation between the intraretinal location of the leakage source and where the fluid accumulated within the retinal layers.
Silicone oil tamponade had a significant impact on the reduction of retinal thickness and that the reduction of ganglion cell layer, outer plexiform layer, and outer nuclear layer thicknesses showed the strongest correlation with worse visual acuity outcome.
Younger patients were more likely to experience early postoperative hypotony.
Subfoveal choroidal thickness was associated with functional and anatomical outcomes after intravitreal ranibizumab injection in eyes with typical neovascular AMD and PCV.
The prevalence of various drusen differed according to the nAMD subtypes, and each drusen type was strongly associated with the choroidal thickness. Typical nAMD showed distinct features according to the accompanying drusen type.
Pulsating PCV showed distinctive features including a relatively younger patient age at presentation, and a haemorrhagic tendency (especially extensive). However, the use of PDT did not directly increase the risk of haemorrhage in pulsating PCV patients.
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