Sungkyunkwan University · 医学
Professor Sung Hyun Lee's research lab specializes in clinical and translational pain medicine, with a focus on developing innovative, evidence-based interventions for chronic and neuropathic pain conditions. The lab integrates advanced technologies such as machine learning to predict postoperative outcomes like postoperative nausea and vomiting (PONV) and chronic low back pain, enhancing personalized patient care. Key research directions include evaluating novel therapeutic approaches such as PDRN prolotherapy and ultrasound-guided nerve blocks (e.g., ESPB) for musculoskeletal and neuropathic pain. The lab also investigates the pathophysiology of headache disorders, particularly those related to intranasal anatomical factors, aiming to improve diagnostic accuracy and treatment strategies.
Figures are computed from collected data and may differ slightly.
A single preoperative injection of ESPB with ropivacaine may improve acute postoperative analgesia and emergence agitation in patients undergoing VATS.
<i>Background and Objectives</i>: Chronic lower back pain (LBP) is a common clinical disorder. The early identification of patients who will develop chronic LBP would help develop preventive measures and treatment. We aimed to develop machine learning models that can accurately predict the risk of chronic LBP. <i>Materials and Methods</i>: Data from the Sixth Korea National Health and Nutrition Examination Survey conducted in 2014 and 2015 (KNHANES VI-2, 3) were screened for selecting patients w
PDRN prolotherapy may improve the conservative treatment of painful rotator cuff tendinopathy for a specific subset of patients.
We developed and validated machine learning models for predicting PONV in the first 24 h. The machine learning model showed better performance than the Apfel model in predicting PONV.
SC administration of PDRN results in the attenuation of allodynia and activation of astrocytes in neuropathic pain or CRPS models. We propose that PDRN can have significant potential advantages in neuropathic pain treatment.
<b>Background:</b> When intranasal contact points are the cause of headache and facial pain, opinions regarding whether to remove intranasal contact points when they are believed to be the cause of headache and facial pain are divided.<b>Clinical Presentation:</b> A 46-year-old woman visited the authors' pain clinic with complaints of right nasal pain accompanied by frontotemporal headache. She first met an Otorhinolaryngologist and a neurologist. Based on nasal endoscopy and pain pattern, they
Established conventional treatments for postherpetic neuralgia (PHN) and postherpetic itch (PHI) are difficult and often disappointing. In this study, the authors investigated the effect and mechanisms of extracorporeal shockwave therapy (ESWT) on pain and itch associated with PHN and PHI.Thirteen patients, 50 to 80 years of age, with symptoms associated with PHN or PHI (duration of persistent pain >3 months) and complaints of pain or itch rated >4 on a numerical rating scale (NRS), were include
Trigeminal neuralgia, foramen ovale, trigeminal ganglion, 3-dimensional (3D) facial computed tomography (CT) scans.
Herpes zoster (HZ) results from the reactivation of latent varicella-zoster virus in the dorsal root ganglion neurons. The most common complication of HZ is post-herpetic neuralgia (PHN), characterized by persisting neuropathic pain in the affected dermatome after the rash recedes. The immune system is more compromised in older people, which leads to an increase in the incidence of HZ and PHN. Several studies have revealed that HZ or PHN is associated with an increased risk of malignancy in immu
Rearrangement and amplification of the D-type cyclin genes have been reported in human cancer. Previous studies have demonstrated that Ras-mediated skin tumorigenesis depends on pathways that act through cyclin D1 and D2; however, the role of cyclin D3 remains unknown. The present study demonstrates that cyclin D3 ablation does not affect keratinocyte proliferation, but instead increases apoptosis levels in the bulge region of the hair follicle. Consequently, cyclin D3 ablation reduces skin papi
TFFP using the Foramoon® device (Mcarekorea, Seongnam-si, Gyeonggi-do, Republic of Korea) appeared to be effective for managing patients with LFS and LCS, who were refractory to conservative care.
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