東京大学 · 農学・生物学
Asami教授の研究室では、植物ホルモンの働きを解明するための化学的アプローチを柱としており、特にブRAシノステロイド（BR）の生合成阻害剤であるブレジノラゾールの開発とその作用機序解明を進めています。植物の矮性化を誘導する化学化合物のスクリーニングから始まり、BR代謝経路の制御機構を解明する研究が展開されています。また、化学バイオロジー的手法を用いた植物ホルモン機能の解析も重要な研究テーマです。
Figures are computed from collected data and may differ slightly.
Screening for brassinosteroid (BR) biosynthesis inhibitors was performed to find chemicals that induce dwarfism in Arabidopsis, mutants that resembled BR biosynthesis mutants that can be rescued by BR. Through this screening experiment, the compound brassinazole was selected as the most potent chemical. In dark-grown Arabidopsis, brassinazole-induced morphological changes were nearly restored to those of wild type by treatment with brassinolide. The structure of brassinazole is similar to pacrob
Brassinazole, a synthetic chemical developed in our laboratory, is a triazole-type brassinosteroid biosynthesis inhibitor that induces dwarfism in various plant species. The target sites of brassinazole were investigated by chemical analyses of endogenous brassinosteroids (BRs) in brassinazole-treated Catharanthus roseus cells. The levels of castasterone and brassinolide in brassinazole-treated plant cells were less than 6% of the levels in untreated cells. In contrast, campestanol and 6-oxocamp
Plant hormones are small molecules that play versatile roles in regulating plant growth, development, and responses to the environment. Classic methodologies, including genetics, analytic chemistry, biochemistry, and molecular biology, have contributed to the progress in plant hormone studies. In addition, chemical regulators of plant hormone functions have been important in such studies. Today, synthetic chemicals, including plant growth regulators, are used to study and manipulate biological s
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