Ulsan National Institute of Science and Technology · 生化学・遺伝学・分子生物学
Professor Tae-Eun Park's research lab specializes in developing advanced human microphysiological systems (MPS) and organ-on-a-chip platforms to model human organ barriers, with a focus on the blood-brain barrier and gastric mucosal barrier. The lab integrates induced pluripotent stem cells (iPSCs), primary human cells, and microfluidic technologies to create physiologically relevant in vitro models that recapitulate in vivo barrier functions, cell-cell interactions, and host-microbe dynamics. Their work emphasizes precision drug testing by addressing key limitations of traditional platforms, such as small molecule absorption in PDMS and immature epithelial phenotypes, enabling more accurate preclinical drug screening and disease modeling. The lab's innovative approaches support translational research in neurodegenerative diseases, gastrointestinal infections, and targeted therapeutics.
Figures are computed from collected data and may differ slightly.
The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we describe an in vitro microfluidic organ-on-a-chip BBB model lined by induced pluripotent stem cell-derived human brain microvascular endothelium interfaced with primary human brain astrocytes and pericytes that recapitulates the high level of barrier function of the in vivo human BBB for at least one week in culture. The endothe
In drug discovery, human organ-on-a-chip (organ chip) technology has emerged as an essential tool for preclinical testing, offering a realistic representation of human physiology, real-time monitoring, and disease modeling. Polydimethylsiloxane (PDMS) is commonly used in organ chip fabrication owing to its biocompatibility, flexibility, transparency, and ability to replicate features down to the nanoscale. However, the porous nature of PDMS leads to unintended absorption of small molecules, crit
Several stomach diseases are attributed to the dysregulation of physiological function of gastric mucosal barrier by pathogens. Gastric organoids are a promising tool to develop treatment strategies for gastric infections. However, their functional features of in vivo gastric mucosal barrier and host-microbe interactions are limited due to the lack of physiological stimuli. Herein, a human stomach micro-physiological system (hsMPS) with physiologically relevant gastric mucosal defense system is
The highly specialized human brain microvascular endothelium forms a selective blood-brain barrier (BBB) with adjacent pericytes and astrocytes that restricts delivery of many pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we describe an in vitro microfluidic ‘organ-on-a-chip’ (Organ Chip) model of the BBB lined by induced pluripotent stem cell-derived human brain microvascular endothelium (iPS-BMVEC) interfaced with primary human brain astrocytes and pericytes t
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