Yonsei University · 医学
Professor Tae-im Kim's research lab specializes in anterior segment ophthalmology, with a focus on corneal diseases, refractive surgery, and retinal disorders in premature infants. The lab investigates the pathogenesis and clinical management of conditions such as corneal haze after PRK, the impact of mitomycin C on corneal healing, and the effects of anti-VEGF agents like bevacizumab on epithelial repair. It also explores the role of ocular surface parameters, including lipid layer thickness, in diagnosing dry eye and related disorders. The lab combines clinical data analysis with in vitro and in vivo experimental models to improve surgical outcomes and patient care.
Figures are computed from collected data and may differ slightly.
To investigate the postnatal risk factors of retinopathy of prematurity (ROP), we analysed demographic and clinical data abstracted from the medical records of 425 premature babies who were examined for ROP between January 1994 and December 1998 at Asan Medical Centre, Seoul, Korea. ROP developed in 20.7% of the cases studied. A gestational age (GA) of < or = 28 weeks and birthweight (BW) of < or = 1000 g were the most significant risk factors. Ventilator care for > or = 48 h, apnoea, and use of
Wavefront-guided customized ablation reduced the increase of high order aberrations resulting from LASIK. In terms of visual acuity, patient preference, and mesopic contrast sensitivity, wavefront-guided customized ablation produced slightly-but not statistically significant-better results.
MMC is a potent inhibitor of corneal haze induced by PRK. MMC reduced the number of keratocytes and fibroblasts after PRK and UV-B irradiation. Although MMC would improve the clinical results of PRK, it has significant toxicity on corneal keratocytes, which did not disappear until 3 months after PRK.
Mitomycin C induced apoptosis, not necrosis, in cultured corneal keratocytes through the caspase pathway-specifically, caspase-8 and -9-related to the mitochondrial pathway.
Lipid layer thickness measurements using a new interferometer are significantly affected by demographic factors such as age, sex, ocular surgical history, and MGD type. Therefore, all of these factors must be considered in the diagnosis of ocular surface diseases.
Bevacizumab delayed corneal epithelial wound healing and inhibited integrin expression. When bevacizumab is used to reduce the development of new corneal vessels, slight delays in epithelial wound healing are possible and cellular proliferation is to be expected.
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