Hokkaido University · Medicine
Takanori Teshima 교수의 연구실은 이뮤노이솔레이션 및 이뮤노모odulation을 중심으로 한 이식면역학과 암의 면역조절 메커니즘을 연구하고 있습니다. 특히 간이성면역반응을 억제하면서도 암세포에 대한 방어 기능을 유지하는 IL-11의 역할을 밝혀내는 데 초점을 맞추고 있으며, 이는 이식 후 합병증 예방과 함께 암의 면역치료 전략 개발에 기여합니다. 또한 성인T세포 림프종 등 혈액계 암에서 뇌신경계 침윤의 기전과 임상적 특성에 대해서도 깊이 있는 분석을 수행하고 있습니다.
Figures are computed from collected data and may differ slightly.
We recently showed that IL-11 prevents lethal graft-versus-host disease (GVHD) in a murine bone marrow transplantation (BMT) model of GVHD directed against MHC and minor antigens. In this study, we have investigated whether IL-11 can maintain a graft-versus-leukemia (GVL) effect. Lethally irradiated B6D2F1 mice were transplanted with either T cell-depleted (TCD) bone marrow (BM) alone or with BM and splenic T cells from allogeneic B6 donors. Animals also received host-type P815 mastocytoma cells
Central nervous system (CNS) involvement was reviewed in 99 patients with adult T-cell leukemia/lymphoma (ATLL). Fifteen episodes of CNS involvement developed in ten of 99 patients (10.1%); nine had leptomeningeal involvement, whereas two developed intracerebral invasion, one developed cord involvement, and one developed both. CNS involvement was more frequent in the lymphoma type than in the other types of ATLL. Nuchal rigidity was not common (33%) and a syndrome of inappropriate secretion of a
Open papers in the app to read, cite, and organize with AI.
