Kyoto University · Medicine
타카오 카토 교수의 연구실은 심 heart failure(심부전)의 대사 변화, 영양 상태 평가, 치료 전략의 임상적 영향에 중점을 두고 있습니다. 특히 심부전 환자의 대사 프로파일 변화와 DCA의 대사 조절 작용, CONUT 점수를 통한 영양 상태 평가, 그리고 MRA 사용이 심부전 재입원에 미치는 영향 등 임상 기반의 심장질환 관리 전략을 탐구하고 있습니다. 또한 중증 대동맥판막 협착 환자의 死亡 원인 분석을 통해 심장성 사망과 비심장성 사망의 특성과 관련 요인을 규명하고 있습니다.
Figures are computed from collected data and may differ slightly.
Left ventricular hypertrophy or CHF is associated with a distinct change in the metabolic profile of the heart. DCA attenuated the transition associated with increased energy reserves, activation of the pentose phosphate pathway, and reduced oxidative stress.
The high controlling nutritional status (CONUT) score that represents poor nutritional status has been acknowledged to have prognostic implications in chronic heart failure. We aimed to investigate its role in acute decompensated heart failure (ADHF). Using the data from an multicenter registry that enrolled 4056 consecutive patients hospitalized for ADHF in Japan between 2014 and 2016, we analyzed 2466 patients in whom data on the components of the CONUT score at hospital presentation were avai
Use of MRA at discharge from ADHF hospitalization did not appear to be associated with lower mortality but was associated with a lower risk of heart failure readmission. This finding suggests that MRA treatment at discharge may have minimal, if any, clinical advantages.
Whether patients with severe aortic stenosis (AS) die because of AS-related causes is an important issue for the management of these patients. We used data from CURRENT AS registry, a Japanese multicenter registry, to assess the causes of death in severe AS patients and to identify the factors associated with non-cardiac mortality. We enrolled 3815 consecutive patients with a median follow-up of 1176 days; the 1449 overall deaths comprised 802 (55.3%) from cardiac and 647 (44.7%) from non-cardia
The mode of death was similar among the heart failure subtypes. Given the nonnegligible incidence of sudden cardiac death in patients with HFpEF found in this study, further studies appear to be warranted to identify a high-risk subset in this population.
UMIN000012140; Post-results.
NCT02334891, UMIN000015238.
Psoriasis vulgaris was independently associated with CHD in a hospital-based population in Japan.
Independent of baseline albumin levels, an increase in albumin during index hospitalization was associated with a lower 1-year risk for a composite of all-cause death and hospitalization in patients with acute heart failure.
A high CRP level (>10 mg/L) at discharge from an ADHF hospitalisation was associated with an excess mortality risk at 1 year. TRIAL REGISTRATION DETAILS: https://clinicaltrials.gov/ct2/show/NCT02334891 (NCT02334891) https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000017241 (UMIN000015238).
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