The University of Tokyo · Biochemistry, Genetics and Molecular Biology
타카시 후쿠야 교수의 연구실은 발달 생물학과 분자 유전학을 기반으로 유전자 발현의 시공간적 정밀 조절 메커니즘을 연구합니다. 주로 전사 조절을 담당하는 엔ハン서와 코어 프로모터의 상호작용이 유전자 발현의 버스트 동역학에 어떻게 영향을 미치는지, 실시간 생체 내 영상 분석을 통해 규명하고자 합니다. 또한 청각 장애와 관련된 분자 기전, 예를 들어 내이 출혈성 펌프 등에서의 분자적 변화를 다루며, 청각 신경 생물학과 유전자 조절 메커니즘의 기초를 탐구하고 있습니다.
Figures are computed from collected data and may differ slightly.
Regulatory interactions between enhancers and core promoters are fundamental for the temporal and spatial specificity of gene expression in development. The central role of core promoters is to initiate productive transcription in response to enhancer's activation cues. However, it has not been systematically assessed how individual core promoter elements affect the induction of transcriptional bursting by enhancers. Here, we provide evidence that each core promoter element differentially modula
Transcriptional bursting is a prevalent feature of gene expression. The transient assembly of transcription factor clusters at regulatory DNAs is critical to control bursting dynamics.
Audiological findings in 40 patients with surgically confirmed idiopathic perilymphatic fistula were investigated. Most patients complained of roaring tinnitus, hearing impairment, ear fullness, and hyperacusis. However, a popping sound and a streaming water-like sound were noticed only in 8. Pure-tone sensitivity included every kind of hearing impairment, from sudden profound, to normal sensitivity. Development of hearing impairment was sudden, and deteriorated further, fluctuating in order of
The effects of laceration of the round window membrane were investigated using the auditory brainstem response in guinea pigs with or without middle ear effusion. Sensorineural hearing impairment occurred in the lower basal turn of the cochlea with middle ear effusion. However, only temporary and mild hearing loss was observed in guinea pigs without middle ear effusion.
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