京都大学 · 医学
Takayoshi Shimizu教授の研究室は、変形性腰椎疾患における脊髄圧迫の緩和と脊椎固定の臨床的成績向上を目的として、画像診断に基づく個別化された手術戦略の確立に注力しています。特に、間接的脊柱接着術(LIF)による脊柱管拡張効果や、酸化チタン被膜を施した生体活性ポリエーテルエテルケトン(bioactive PEEK)インプラントの骨接着力向上に関する研究が特徴です。また、脊椎の sagittal balance と下肢補償行動の関連性を解明し、術前評価における下肢補償の予測可能性を高めることにも貢献しています。
Figures are computed from collected data and may differ slightly.
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LIF with indirect decompression for degenerative lumbar disease with severe canal stenosis provided successful clinical outcomes, including restoration of disc height and indirect expansion of the thecal sac. Severe canal stenosis diagnosed on preoperative MRI itself is not a contraindication for indirect decompression surgery.
The TiO2-coated bioactive PEEK implant demonstrated better fusion rates and bone-bonding ability than did the uncoated PEEK implant in the canine anterior cervical fusion model. Bioactive PEEK, which has bone-bonding ability, could contribute to further improvements in clinical outcomes for spinal interbody fusion.
ASD patients with increased CrSVA-H, which represents cranio-hip anterior imbalance, demonstrated a higher prevalence of LE compensation, especially knee flexion, compared to those with neutral and posterior shift of CrSVA. PT represents the extent of LE compensation in patients with spinal sagittal malalignment. Using the cutoff value of PT determined in this study, surgeons can preoperatively estimate the extent of LE compensation without obtaining a full-body radiograph.
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The CT-confirmed fusion rate of OCF was 77.2% over an average 89.7-month follow-up. Compensatory sagittal alignment change can occur in the unfused subaxial segments in conjunction with the alignment change in the instrumented OC segments, whereas the horizontal gaze was maintained. Strong consideration for the intraoperative measurement of the OC2A should be given during OCF to minimize both early and long-term complications.Level of Evidence: 4.
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