東京工業大学 · 生化学・遺伝学・分子生物学
石尾武彦教授の研究室は、ゲノム生物学と進化ゲノミクスを柱に、ヒトとチンパンジーをはじめとする霊長類のゲノム比較を通じて、人間特有の遺伝的特徴の解明を進めています。また、発酵酵母の系統的・遺伝的起源の解明にも注力しており、特にラージャービール酵母の進化歴を次世代シーケンシングを用いて解明しています。これらの研究を通じて、ゲノムの構造的多様性とその進化的意義を解き明かすことを目指しています。
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The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate posit
The lager beer yeast Saccharomyces pastorianus is considered an allopolyploid hybrid species between S. cerevisiae and S. eubayanus. Many S. pastorianus strains have been isolated and classified into two groups according to geographical origin, but this classification remains controversial. Hybridization analyses and partial PCR-based sequence data have indicated a separate origin of these two groups, whereas a recent intertranslocation analysis suggested a single origin. To clarify the evolutio
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