慶應義塾大学 · 医学
Takehiko Mori教授の研究室は、移植免疫学を基盤とし、特に移植片対宿主疾患（GVHD）と移植片対がん効果（GVL）のバランス解明を主眼としています。マウスモデルを用いた実験により、T細胞の移行が宿主造血機能に及ぼす影響を解析しており、臨床応用に結びつく免疫調節メカニズムの解明を目指しています。また、タクロリムスの血中濃度と急性GVHD発症の関連性についての臨床的検討も進めています。
Figures are computed from collected data and may differ slightly.
The influence of graft-versus-host (GVH) reaction on the host hematopoietic cells clinically manifests itself both as adverse reactions in transfusion-associated GVH disease (GVHD) and as a therapeutic graft-versus-leukemia (GVL) effect in either donor lymphocytes transfusion (DLT) or allogeneic bone marrow (BM) transplantation. We examined the effect of GVH reaction on the host hematopoiesis in the murine parent-into-F1 (P1 --> F1) model of GVHD. The systemic transfer of 5 x 10(7) of C57BL/6 (B
Only limited data are available regarding the relationship between blood concentration of tacrolimus and its efficacy in preventing acute graft-versus-host disease (aGVHD). We retrospectively evaluated the effects of the whole blood concentration of tacrolimus, which was measured by an automated microparticle enzyme immunoassay, early after allogeneic hematopoietic stem cell transplantation (HSCT) upon the development of aGVHD. Sixty patients, who underwent allogeneic HSCT from serologically hum
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